The Vespiary

The Hive => Chemistry Discourse => Topic started by: psyloxy on November 13, 2003, 04:53:00 PM

Title: acetic / propionic anhydride from NaO(Me)Ac + TsCl
Post by: psyloxy on November 13, 2003, 04:53:00 PM

Patent DE123052 (http://l2.espacenet.com/dips/viewer?PN=DE123052&CY=gb&LG=en&DB=EPD)

Ac₂O

382 parts by weiht of TsCl are well mixed with 328 parts of dry NaOAc and heated / cooled by a reflux condenser. Temperature quickly rises to 140°C. After a couple of hours the produced Ac₂O is distilled from the salt mass .

MeAc₂O
Equal parts TsCl and sodium propionate are well mixed and held refluxing at ~150°C for multiple hours. The propionic anhydride is  removed by vac. distillation.

There's also methods for the preparation of AcCl, salicylic acid chloride and benzoic acid anhydride in the patent.

--psyloxy--
"I'd rather be a small part of something great, than a big part of a pile of shit" - Josh Homme