Yield 95.5%
Reagent Br2
Solvent MeOH
Time 1h
Temp ambient
Is it because after the monobromination of anisaldehyde the 3-Br-4-MeO-BA is too deactivated or what ?? I would like to say I don't understand chemistry anymore, but I never understood the basics anyway.
[1]Manchand, Percy S.; Belica, Peter S.; Wong, Harry S.; SYNCAV; Synth.Commun.; EN; 20; 17; 1990; 2659-2666
--psyloxy--
Post 421565 (https://www.thevespiary.org/talk/index.php?topic=11500.msg42156500#msg42156500)
(Rhodium: "Chinese Translation needed", Novel Discourse) from benzaldehyde. By the way, I searched the literature for syntheses of 2,5-dibromo-BA similar to the chinese ref, with no luck.