One-pot synthesis of Tryptophols & Tryptamines

[Rhodium]

Tandem Hydroformylation/Fischer Indole Synthesis: A Novel and Convenient Approach to Indoles from Olefins
Petra Köhling, Axel M. Schmidt, and Peter Eilbracht
DOI:

10.1021/ol0350184

Abstract

A novel one-pot synthesis of indole systems via tandem hydroformylation/Fischer indole synthesis starting from olefins and arylhydrazines is described. This tandem procedure leads directly to 3-substituted indoles if unsubstituted phenylhydrazine is used and to 3,5- respectively 3,7-disubstituted indoles if para- or ortho-substituted arylhydrazines are used.