A new approach to the ergoline skeleton

[pHarmacist]

Tetrahedron 59 (2003) 4281–4286

(http://pharmacist-hive.tripod.com/ergolinenew.pdf)
Mária Incze, István Moldvai, Eszter Temesvári-Major, Gábor Dörnyei, Mária Kajtár-Peredy and Csaba Szántay

Abstract: Starting from N-pivaloyl-Uhle's ketone a new synthetic approach to the ergoline skeleton has been elaborated. Ring D of the tetracyclic skeleton was formed by an intramolecular Dieckmann-condensation of a diester, obtained in a Reformatsky reaction of a properly substituted derivative of N-pivaloyl Uhle's ketone followed by elimination of water.