Author Topic: questions about DMT synth  (Read 1770 times)

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penroc3

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questions about DMT synth
« on: August 03, 2004, 10:13:00 PM »
well this is my first post here :-[  , swim has found a source for tryptamine, ethyl formate, and was wondering if getting eather of these would throw up red flags.  swim is not to educated on the legal status of tryptamine,  swim was going to do a synth via the one in tihkal the one from tryp. and ethyl formate seems easy enough for a first or second synth :P

terbium

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LAH
« Reply #1 on: August 04, 2004, 08:17:00 PM »
This synthesis requires Lithium Aluminum Hydride and anhydrous THF. Probably not a good first synthesis.


penroc3

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???
« Reply #2 on: August 05, 2004, 05:54:00 PM »
can you recomenmd a different rout to this then... and why do you say it is not a good idea.. dangerous or just complicated?

Lego

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no need to ask, so much info available
« Reply #3 on: August 06, 2004, 01:47:00 PM »
can you recomenmd a different rout to this then...

Post 519197

(Lego: "Synthetic routes to dialkyltryptamines", Tryptamine Chemistry)



and why do you say it is not a good idea.. dangerous or just complicated?
both, see e.g.

Post 376864

(Rhodium: "Lab-size Mushroom Cloud", Methods Discourse)
. For more information UTFSE!


Offline nomud2.0

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Re: questions about DMT synth
« Reply #4 on: July 18, 2017, 02:35:30 AM »
PhN=O + CH3C=OCH2CH2NR2-->PhN=CHC=OCH2CH2NR2
reduce the anil (imine)Schiff's,several ways to,then aceylate or benzoylate
the  1 position-NH, to protect.For PhN(Ac)CH2C=OCH2CH2NR2.
Cyclize,dehydrate (this is hydroxy alkylation dehydration best acid cat
is polyphosphoric acid PPA or phosphoric acid.For the tryptamine.
Sulfuric acid might work to but side rxn of aryl sulfonation complicates.

Note: condensation of nitrosobenzene and N,N-dialkylamino-3-butanone done RT
several days for kinetic mechanism in base tends to condense at less substituted carbon next to the carbonyl. Vs thermodynamic is higher temps, acid cat tends to condense at the more  substituted carbon next to the carbonyl.The N,N-dialkylamino-3-butanone starting material is standard Mannich rxn fair, 70% yields from acetone, formaldehyde and secondary amine.


Note:condensation of nitrosoarenes, usually done in aprotic solvent,many types of bases are used and excluding O2 to reduce nitrones is essential.This is Ehrlich-Sacks rxn.Nitroso arenes can and usually are spontaneously explosive and aren't stored,hazardous to move.Contact with self is dangerous too.
« Last Edit: July 30, 2017, 08:06:21 PM by nomud2.0 »
All that and a bag of chips too ;)

Offline nomud2.0

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Re: questions about DMT synth
« Reply #5 on: July 18, 2017, 03:00:30 AM »
The  resulting tryptamine is 1-acyl or 1-benzoyl tryptamine that is deacylated or debenzoylated fairly easy by hydrolysis.This is basic standard fair removing the 1 position acyl/benzoyl protection should be in most books as Green's or most hetrocyclic chem books.
« Last Edit: July 18, 2017, 06:54:47 AM by nomud2.0 »
All that and a bag of chips too ;)