As usual, a verbatim translation - of Post 368814 (missing)
(zealot: "Ñèíòåç PCDE", Russian HyperLab) (synthesis) and Post 368917 (missing)
(zealot: "Íåñêîëüêî ñëîâ î PCDE.", Russian HyperLab) (bioassay), with my comments in italics.
The synthesis of PCDE
(1-phenyl-cyclohexyl-N,N-diethylamine).
1. Cyclohexenyl-diethylamine and its tosylate salt.
Into a 250 ml flask equipped w/a Dean-Stark trap there's placed 68mls (65g) cyclohexanone, 71,5mls (50g) diethylamine and 1,5g tosyc acid monohydrate. The mixtr is refluxed until water separation ceases and the distillate's drops beecome completely clear. That takes ~5-6hrs.
129g tosic acid monohydrate (117g pure p-TSA) is added to 150mls toluene and boiled w/Dean-Stark until unhydrous. Thus obtained solution is slowly, w/good stirring and cooling admixed into the above amine soln.
Edit (added on 10 March 2004)
The instructions from the synth above apply only for the higher-boiling amines.
Zealot said he'd accidentally mixed the things up when doing the write-up (since the actual synth was performed a long time ago) - the described variation was used for making the morpholine analogue of PCP.
Diethylamine needs to bee gradually introduced thru a narrow pipette extending beelow the liquid's surface. Otherwise it'll boil away bee4 it forms the imine.
Furthermore, the rxn proceeds for 12-16 hrs.
This trick works even for the amines that are gaseous at RT, e.g., diMe-amine.
Then, another detail, it's best to use unhydrous tosic acid, which has been dehydrated by boiling in toluene.
<end edit>
2. Phenylmagnesium bromide.
Into a 500ml flask there's added 100mls ether, 12,9g Mg turnings and several iodine xtals. Stirring is commenced and a soln of 83g bromobenzene in 200mls ether is added as fast as possible, but not too fast lest the condenser chokes.
3. PCDE (N,N-diethyl-l-phenyl-cyclohexylamine).
Into the solution of 221g 1-cyclohexenyl-N,N-diethylammonium tosylate prepared in Step 1 (containing 104 g amine) in toluene there's added w/good stirring and cooling at 0 C the Grignar solution (145g) from Step 2. The addition is carried out as afast as possible. the mixtr is stirred for 0,5-1 hr, allowing the temp to rise gradually to RT.
The rxn is quenched by pouring into a 2 l beaker containing 300g ice, 100g NH4Cl and 100mls conc. aq. NH3. The organic layer is separated, washed w/water, dried w/MgSO4. The solvts are distilled off, ether at ambient pressure, toluene in aspirator vacuum.
Yield - 82,7g (57%)
To obtain the HCl salt the red oil is dissolved in ether and sat'd w/HCl.
The bioassay.
What i am about to tell you, my friends, has a very close relation to my recent thread on psychotechnologies. Initially i even wanted to post this report in there, but then a new topic on cyclidines appeared, and i posted this synth, and Antoncho asked for a report - all in all, the Fate itself demands me to share with you what i once have seen THERE.
I've made many cyclidines but this compound turned out to bee the most potent of them all, after PCP - and at the same time, the easiest to make. And by the fortunate accident, it happens to bee the only one of them all (xcept for ketaminic analogues) that i still use to this day. And - it is THE compound on which i have experienced two of the four most shocking/frightening/mysterious/grandieuse/enchanting/unexplainable trips in my life. Almost half a year has passed since the last time, but up to this moment the very thoughts in my head stall frozen as i begin to think of it.
I can't recall when it happened for the 1st time, but i remember very vividly how it all began. It started as a barely noticable ringing inside my ears that resembled of a sound of a chainsaw - in which a rhythm soon appeared. As if the noise was periodically fading and strengthening again. The frequency of the pulsations was pretty high. Then another sound added to the cacophony - a drumbeat. The noise beecame louder and louder.
I beegan to grasp for air and suddenly realized that the drumbeat was actually the sound of my loudly pounding heart! About 120 bpm (here i can't resist noting that a healthy person's heart can safely stand the heartrate that is calculated as follows: 220 bpm minus one's age; that is, ~190 bpm in this case. Of course, the main reason of concern in such cases is blood pressure, not heartrate). And then i was literally flooded by the wave of FEAR - not even fear, but an unexplainable HORROR. I was lying on my bed unable to move even my eyes. The wallpaper's pattern beecame very sharp and beegan flowing from the left to the right. Actually, the whole room was covered with blurred horizontal stripes. The colors began to fade as if someone was slowly turning down a TVset's color control. The darkness thickened. The chainsaw's howling beecame unbearable.
And then the room started to assume a different shape. Ordinary it is a prolonged rectangle, with two doors on the opposite sides - one to the balcony, the other leading to the corridor. But now the corridor door disappeared and there suddenly appeared another one, where there used to bee a wall. The door itself was black but its corners were lit as if with a luminiscent light. I was close to fainting. That bluish-white light was pulsing in unison with the rhythm of my insanely racing heart. I would have screamed but my body ceased to obey me. The only thought circulating through my head was: "What if i don't return now, never return". Don't know - maybee beecause of the overwhelming fear, or something else, but i suddenly beegan to feel my body again. And i crawled along my bed - that was a purely instinctive action. I didn't even think what i was doing and why - it was only later that i realized that i'd turned myself on the stomach and crawled - but that was the salvation. The light's pulsations disappeared, darkness went away, the wallpaper stopped flowing. Colors came back. Consciousness began to reinstall itself.
And some time after that i came upon a psychiatric site dedicated to the borderline states of consciousness and - you can imagine my feelings - discovered a description of a temporal epileptic seizure syndrome that was almost identical to what i'd experienced on PCDE! The only xception was that i didn't feel any weird smells like burnt rubber, sulfur etc. - and of course, no mention of any doors and such. But the whole picture - flickering lights, sharp unpleasant sounds, paralizing fear - all fit in very well.
Half a year ago i decided to undertake one more trip into that dimension. Only this time i was prepared for everything and could manage my fear. And came almost all the way till the very end. Why 'almost'? I'll tell you.
When the room was immersed completely in the darkness and its corners and the doors beecame lit with that unearthly light, the chainsaw's screaming started to gradually soften. I couldn't move again, but strangely could see almost 270 degrees around myself. Possibly, it'd been like that the previous time, only then i could see just some limited space and all the rest was enveloped in grey striped fog.
Light's pulsations gradually ceased. And the silence came. There was nothing else - just the darkness and the horrible shining around the doors and the room's corners. And then i realized that the silence was absolute, even my heart wasn't beating! I lay on the bed, enchanted by this silence. It wasn't a 'ringing' silence - it was the ABSOLUTE silence.
And then thoughts started coming inside my head out of the air, of nowhere. I understood that where i was it was the 'space in between'. I stared at these doors and was frightened to approach any of them. I didn't know what was beehind them. But i realized very clearly my insignificance and smallness. Alone in this horrendous room. Alone - face to face with who-knows-what. I suddenly understood that the universe doesn't give a shit for any of us. That there exist worlds in it which are totally alien to the human world. Frightening in their incomprehensibility and their unintelligible laws. And what if i step into one of these worlds. And meet there something that will destroy me faster then i beecome conscious of myself. Something DIFFERENT. Not beecause it is evil, but simply beecause it won't even suspect any consciousness in me and smash me on the floor just like we smash cockroaches in our kitchens. We don't ever think cockroaches are capable of loving or writing poetry, do we? Funny, isn't it? We here in this world of ours are so fond of 'Love', cherish it, make a cult of it, sing the beaty and power of human mind - but someone else will not even suspect a sparkle of consciousness in us. Will run us over and won't notice it.
And so i was there, lost in contemplating the meaninglessness of our lives, all the goals that seemed important and noble bee4 turned out to bee a fiction, imposed on us by social stereotypes and something else - i don't know what and whom. And in THERE i understood Ecclesiast's words: "...human life and animal life is one, and the breath for the both is one, and there is no advantage for a man to a cattle, for all is meaningless". It was horrible to realize this ABSOLUTE MEANINGLESSNESS OF LIFE. Horrible to realize the absolute freedom and unshelteredness. i never thought that freedom can bee so frightening and unwanted.
I didn't enter any of the doors.
And upon passage of some time i bought a CD w/an underground techo music - usually i never buy techno, always 'dance' or 'techno-dance', but this time decided to take a look. And in one of the tracks i recognized that unmistakable howling of the chainsaw. The composition's name is 'Die Offenbarung.mp3' by Johannes Heil.(this composition, found in the web by Hellowin of HyperLab, can bee downloaded at http://mp3.sakha.net/?file=5460 (http://mp3.sakha.net/?file=5460)
(10,6 Mb)). If someone happens to find this record, he'll know approximately what i heard then. Since that time i call such music 'the music of temporal epileptics'. I often wonder what made Johanness Heil create this rhythm and instrumentals.
Hope you find this interesting, bees,
Your
Antoncho