yet another phenylalanine post

[halfkast]

Is the Akabori reaction to reach the feedstock for a HI reduction feasable?

Although there's the benzaldehyde aquisition problem. The reaction will also produce PPA in the mixture which reduces to a more toxic drug I think you said Rh.

The yields suck too. But someone has made an attempt, which was low yielding from methylalanine.

'According to Akabori and Momotani (269), a mixture of an aromatic aldehyde and an amino acid on heating yield alkamines. By means of this reaction, ephedrine and norephedrine were synthesized.'

Is there any authoritative details on the procedure? reaction times, temperature, pH and solvent choice? freebase or salt for phenylalanine? D only, D,L, or L outcomes? Reflux?
Are there any other aromatic aldehydes, more OTC have useful outcomes?

[Rhodium]

UTFSE for "Akabori" and you'll find a lot of articles on the topic, a few awaits translation from german though.

PPA is reduced to regular amphetamine by HI.

[halfkast]

UTFSE for "Akabori" and you'll find a lot of articles on the topic, a few awaits translation from german though.

You know I was going to mention that.
you supplied 4 examples, the first 3 were german, only the final one in english, and that was the one you had doubts about beeing the akabori thats useful for alchemy.

ok, Ill try look for more articles everywhere. im going to hit the pAtents too.
ahah i was looking for patents to synthetic N-alkylated amino acids today    

[SMACK_WHORE]

ok swim has been plauged with ideas about phenyalanine latley...
swim has thought up the following small scale experiment..

1g of phenylalanine is dissolved in 3.642g isopropenol and a catalytic amount of HCl is added.the mixture is then heated to yeild an ester
     QUESTION 1:How much HCl should be used?and how long should it be heated for?
0.0607g Li metal is thrown into the mix and dissolved.this should yeild phenylalininol and isopropenol.
     Question 2: will this above reation work?the origional method involves Na in ethanol to reduce an ester.how could the phenylalinol be isollated?

[java]

You might want to follow this thread to this other thread continued from an older post.....java

Post 516647 (missing)

(java: "Phenylalanine  to amphetamine continuation.....", Serious Chemistry)