I got this submission in an email from Berserker.
Easy Bromosafrole Synthesis by Berserker
This is a revolutionary new method to halogenate ketenes with Markinokov selectivity, by reacting them with a phosphorus trihalogenide in the presence of silicon dioxide catalyst. To make others, just substitute safrole with 10 mols of another alkene.
A suspension is made by stirring 5g of SiO2 (silicon dioxide) into a solution of 10 mol safrole in 25ml dichloromethane. To this, add a solution of 4 mol PBr3 (phosphorus tribromide) in 10ml DCM over the space of 10 minutes at room temperature. The solution is then stirred for around 30 minutes. The SiO2 (still in suspension) is filtered out and then washed with 15ml DCM. The combined liquid is washed with a 10% sodium bicarbonate solution, until no more gas is liberated, then twice with brine, and the organic extract is dried with sodium sulfate. The solvent is then allowed to evaporate, giving pure bromosafrole.
Yields vary between 50% and 100%.
The SiO2 is 70-250 mesh powder, or can be prepared by grinding glass into a fine powder, and washing it with acid. Both silicon dioxide and phosphorus tribromide are unsuspicious chemicals, and can be ordered with ease from well-stocked chemical suppliers.
Reference: Journal of the Brazilian Chemical Society, Vol. 12, No. 5 (2001) (http://jbcs.sbq.org.br/jbcs/2001/vol12_n5/12.pdf)
(http://jbcs.sbq.org.br/jbcs/2001/vol12_n5/12.pdf)
What a coincidence, see:
Post 108668 (missing)
(dormouse: "Delepine RESULTS in ..... -spiceboy", Novel Discourse), look for all the comments from Danielsan, in MARCH 1999!
Post 108559 (missing)
(dormouse: "chloro, bromosafrole @ room temp in 1 hr -danielsan", Novel Discourse), chloro, bromosafrole @ room temp in 1 hr -danielsan ,
Rev Drone and BrightStar "nitpicking" on Danielsan, hehhe 19 NOV 1998!
Post 122782 (https://www.thevespiary.org/talk/index.php?topic=12280.msg12278200#msg12278200)
(dormouse: "visciously beating a dead horse: MDP2-Pol, back from the dead -drone 342", Serious Chemistry), Rev Drone already thinking about epoxides and diols 30 DEC 1998:
"" rev drone
Member posted 01-06-99 11:29 AM
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I have some amazing ref's using NaOCl and a PTC to oxidize olefins to epoxides and diols -- since both of these compounds are readily isomerizable into the methyl ketone, this is effectively a one-pot-shot. PTC's are the stuff of dreams, and with enough research, I think they could be used to quantitatively catalyze water into wine.
One ref for this procedure is:
JACS 107 (1985) 2000
I have a dozen more, but they're not with me.
Still, this is off-top. You want alcohol oxidations, and alcohol oxidations is what you shall recieve. I'll be back...
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-the good reverend drone ""
http://jbcs.sbq.org.br/jbcs/2001/vol12_n5/12.pdf (http://jbcs.sbq.org.br/jbcs/2001/vol12_n5/12.pdf)
near to plagiarism. LT/
WISDOMwillWIN
Check out Post 372701 (https://www.thevespiary.org/talk/index.php?topic=12564.msg37270100#msg37270100)
(Rhodium: "Vogel and Advice", Serious Chemistry) - what I wrote there to pHarmacist is applicable to your post too.