I am not a chemist, so this is all speculation. (Probably all been done before...Ah well
After reading TiHKAL a while...
I noticed that adding 5-MeO almost always increased potency, in several cases by ~5 fold; that it resulted in generally similar effects, though always with signifigant differences; that unwanted negative effects sometimes appeared or were emphasized; that few 5-MeO compounds were visual, and possibly, had less stimulant tendency.
Similarly, with 4-HO there was also usually an increase in potency, slightly less so than with 5-MEO; all "4-HO'ed" tryptamines were orally active, and they tended to emphasize visual and tactile effects as well as conceptual ones.
Then I made a list of all the unmentioned or undertasted compounds that I speculated might have interesting or informative properties.
(I would guess most of these are more involved to make than the better-explored tryptamines and/or unstable...so this may be why they are not 'well characterized' yet. Do they seem practical to make?)
Anyway here is the list.
4-HO-aET
(4-HO-aMT was 'markedly visual' but also toxic at slightly higher potency than aMT)
4-HO-2-ME-DMT
<2-ME-DMT; 80mg; tactile enhancer>
(5-MEO-2-ME-DMT was of slightly reduced potency, tactile, somewhat sedative, some toxicity at higher doses)
4-HO-(2,a DMT)
5-MEO-(2,a DMT)
<2,a-DMT; 400mg; pleasant sedation>
4-HO-NIBT
5-MEO-NIBT
4-HO-NSBT
5-MEO NSBT
(how would these intoxicants react to substituents?)
5-MEO-4-HO-things:
(Are they more potent still than the 5-MEO's alone? Equipotent? Less potent? Visual? Tactile? Interpretive? Auditory? Toxic?)
(mention of 5-MEO-4-HO-MET made in France but no other details were available.)
5-MEO-4-HO-DMT
5-MEO-4-HO-DET (?still vertigo?)
5-MEO-4-HO-MIPT
5-MEO-4-HO-DIPT
5-MEO-4-HO-DPT
5-MEO-4-HO-aMT
5-MEO-4-HO-aET
and why not
5-MEO-4-HO-NSBT
5-MEO-4-HO-NIBT
again how do intoxicants react?)
4,5-MDO-things:
(What effect on effects might this have? And potency?)
4,5-MDO-DMT
4,5-MDO-DET (?still vertigo?)
4,5-MDO-MIPT
4,5-MDO-DIPT (something LSD-like @ 25mg...interesting)
4,5-MDO-DPT
4,5-MDO-aMT
4,5-MDO-aET
and of course
4,5-MDO-NSBT
4,5-MDO-NIBT
buy more than one fish and put a lid on your tank