During the last week the Hendrickson group (Brandeis University), put a beta version of the synthesis planning program SYNGEN on their webpage (only available for MAC OS, Windows and UNIX versions will follow soon).
They also show some output reaction sequences for lysergic acid total syntheses.
http://syngen2.chem.brandeis.edu/syngen.html (http://syngen2.chem.brandeis.edu/syngen.html)
Mac Users: Let us know how it works...
I also liked his other software: http://www.webreactions.net/search.html (http://www.webreactions.net/search.html)
http://rhodium.lycaeum.org (http://rhodium.lycaeum.org)