The Hive > Tryptamine Chemistry
why use a solvent at all?
Lilienthal:
There is nothing like a 'hydrate bond', in a hydrate the water is in the crystal structure. You have to use a solvent in which your compound is soluble, otherwise there wouldn't be a way for the water to escape the crystal. There is a competition between the compound and the molsieve for the water. Obviously the association with the molsieve is many orders of magnitude stronger (otherwise it wouldn't be a drying agent).
wyndowlicker:
Hey now,
Ok so then your saying the best process for releasing the hydrate bond is to disolve in anhydrous solvent then use mole seives to dry.Does anyone have any hard data on this subect or are we guessing. ;) It sounds like theres some worrys about the seives sucking it up.Whats the likely hood of this reducing yields more than if the LSA is dried but under full vacuum at 40C for several hours.both cause yield loss.Whos got the experienced answers related to this particular synthesis. :P
indole_amine:
What about using just an evacuated dessicator filled with molecular sieves; and heat that just to 45°C for several hours (rather than 90°C)?
:)
indole_amine
wyndowlicker:
Hey now,
So the question is does mole seives pose a possible loss of LSA and how much.I guess someone has tried to at least disolve 1/20 to a gram of LSA and dry with mole seives in solvent.We'll see if there is any loss after drying and weighing odviously,anyone have a reference? :P
Lilienthal:
You cannot remove crystal water just by letting it stand over drying agent ::)
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