organic extraction via solvent

[chem_123]

SWIM has around 1 cup of dried and crushed jalepeno peppers, and wished to use IPA to extract and concentrate the active ingredient (the one that makes it spicy).

Short of using a soxhlet extraction process, is it possible to get a yield just soaking the peppers in the IPA then straining...what is left upon evapping the IPA? an oil?

keep in mind this isn't SWIM's attempt at making hash oil, SWIM is trying to do what is described above.
                             
                                               Why?

[former_chemist]

There are a lot of ingredients in there. Capasin (sp?) being the primary one.  Without a steam distillation you will have to use a variety of solvents to get what you want.  Check the Merck for solubilities.

[terbium]

From the Merck Index:

  1811.    Capsaicin. 
  (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide; trans-8-methyl-N-vanillyl-6-nonenamide; N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-trans-6-enamide; Axsain (Euroderma); Mioton (Pharmakhim); Zostrix (GenDerm).  C18H27NO3; mol wt 305.42.  C 70.79%, H 8.91%, N 4.59%, O 15.72%. 
    Pungent principle in fruit of various species of Capsicum, Solanaceae.  Isoln from paprika and cayenne:  Thresh, Pharm. J. and Trans. 7, 21 (1876); Micko, Z. Nahr. Genussm. 1, 818 (1898).  See Beilstein 13, suppl. I, 322.  Early structure study:  Nelson, J. Am. Chem. Soc. 42, 597 (1920).  Synthesis:  Spth, Darling, Ber. 63, 737 (1930); L. Crombie et al., J. Chem. Soc. 1955, 1025; O. P. Vig et al., Indian J. Chem. 17B, 558 (1979).  Constitution and biosynthesis:  D. J. Bennet, E. W. Kirby, J. Chem. Soc. C 1968, 442.  Pharmacology:  Molnar et al., Acta Physiol. 35, 369 (1969).  Capsaicin is a powerful irritant; initial administration causes intense pain.  Prolonged treatment causes insensitivity to painful stimuli and induces selective degeneration of certain primary sensory neurons:  G. Jancso et al., Nature 270, 741 (1977); R. Gamse, Arch. Pharmacol. 320, 205 (1982); P. Holzer et al., Neurosci. Letters 31, 253 (1982).  Neuronal depletion of substance P, q.v.:  T. M. Jessell et al., Brain Res. 152, 183 (1978); T. L. Yaksh et al., Science 206, 481 (1979).  Capsaicin pretreatment also induces long-lasting desensitization of airway mucosa to various mechanical and chemical irritants:  J. M. Lundberg, A. Saria, Nature 302, 251 (1983).  Preliminary clinical evaluation in chronic postherpetic neuralgia:  J. E. Bernstein et al., J. Am. Acad. Dermatol. 17, 93 (1987).  Reviews:  Molnar, Arzneimittel-Forsch. 15, 718 (1965); Walker, Gavern, Mfg. Chem. Aerosol News 39 (6), 35 (1968); R. M. Virus, G. F. Gebhart, Life Sci. 25, 1273 (1979); Y. Monsereenusorn et al., CRC Crit. Rev. Toxicol. 10, 321-339 (1982).
    Monoclinic, rectangular plates, scales from petr ether, mp 65 deg.  bp0.01 210-220 deg (air-bath temp).  uv max:  227, 281 nm (.epsilon. 7000, 2500).  Burning taste, one part in 100,000 can be detected by tasting.  Practically insol in cold water.  Freely sol in alc, ether, benzene, chloroform; slightly sol in CS2.

          USE:  As a tool in neurobiological research.
          THERAP CAT:  Topical analgesic. 

[chem_123]

Monoclinic, rectangular plates, scales from petr ether, mp 65 deg.  bp0.01 210-220 deg (air-bath temp).  uv max:  227, 281 nm (.epsilon. 7000, 2500).  Burning taste, one part in 100,000 can be detected by tasting.  Practically insol in cold water.  Freely sol in alc...

will it bee an oil when the alc. is evapped? or a scale??

                             
                                               Why?

[El_Zorro]

I think I heard somewhere that the spicy in peppers was crystalline in its pure form.
Do not go gentle into that good night.  Rage, Rage, against the dying of the light.  --Dylan Thomas

[chem_123]

the award for excellence goes to...SWIM's just kidding around...SWIM'll let the bees know the results...prolly won't bee much from a cup of dried peppers...oh hey, what about purification...just an A/B? cold tone wash?
SWIM wants it's shit to bee strong, that's why the purification question
                             
                                               Why?

[acid_egg]

So the Michellin star goes to .....

So wotcha makin'....hot sauce or home-made pepper spray?......no don't answer that.
(rated as:eggsellent)

[chem_123]

tricks are for kids
SWIM really likes it's tricks
hot sauce of course , SWIM's not sure if it's hot sauce is gonna bee the best that SWIM can make short of using the soxhlet or any other glassware for that matter, the IPA is tangerine in color after being strained a la coffee filter... after the IPA evapps off, SWIM'll update on the result of the end product to evaluate if that's the way to make hot sauce or not
                             
                                      Why?