A possible way around this would be to use the pure enzyme (alpha decarboxylase), rather than the whole organism; this enzyme is commercially available in large quantities (used occasionally in brewing). Any thoughts?
The reason I bring this up is that it would make an excellent springboard for further chemical shennanigans -- 3,4-methylenedioxycathinones, methylenedioxy-4-methylaminorex analogs, and a slew of other goodies.
-drone #342
Labrat
Member posted 10-15-98 09:56 AM
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That MD-aminoxazoline can be synthesized in two ways from the aminoalcohol:
1)reaction with a halogencyan, BrCN/ClCN
2)reaction with an isocyanate (forming the substituted urea), then cyclisation with a halogenating agent, e.g. SOCL2.
I've been scanning some relevant articles on this topic very recently. They're from the Arch. Pharm. and Eur. JMC. If you're interested I can mail them to ya. Lr/
Rhodium
Administrator posted 10-15-98 01:29 PM
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I'm VERY interested.
Labrat
Member posted 10-16-98 10:22 AM
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I'll send the articles to you, Rhodium, so everybody can enjoy them! They're written in German, so I don't hope this will give problems. Expect to find the first one in your mailbox soon! Lr/
Rhodium
Administrator posted 10-16-98 11:20 AM
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Thank you! German is all right with me.
Mobius
Member posted 10-30-98 02:23 PM
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For your information the MD version of aminorex (or methyl-aminorex) have been tested for anorexigenic effects on rats up to 150 mg / kg with no concluent results. So, I would not expect them to be active as emphatogenes.
(See Poos et al. ref. given in the Merck under aminorex; synthesis...)