The Vespiary

The Hive => Methods Discourse => Topic started by: psycosmo on May 11, 2002, 05:12:00 AM

Title: Questions about Borohydride + amides, carboxylic
Post by: psycosmo on May 11, 2002, 05:12:00 AM

In the file nabh4.carboxylic it discusses carboxylic acids reacting with secondary and primary amines to form secondary and tertiary amines. Does anyone know if this can also be made to work with ammonia to result in primary amines.
Also, all the examples of amide reduction involve cyclic secondary and teriary amides. Does this necessarily have to be the case?
It seems to in general more difficult to get info about primary amine synthesis. Is this because it is more difficult or are primary amines of less interest to researchers?

Title: yeah ive noticed that its hard to get info about ...
Post by: psycosmo on July 24, 2002, 03:23:00 PM

yeah ive noticed that its hard to get info about primary amines as well. Pretty annoying...

Title: In most reactions, the yields are generally lower ...
Post by: Rhodium on July 24, 2002, 06:07:00 PM

In most reactions, the yields are generally lower when using ammonia or primary amines, so researchers usually avoid publishing results involving that class of compounds, as they feel they will earn higher status by only having 75-99% yield reactions in their papers, and no ugly-looking primary amine in 27-33% yield.