a friend still suffering from tourette's syndrome

[mysterious]

hello bees,

some time ago i wrote that a friend of SWIM suffers from tourette'S syndrome. when he first tried MDMA, the symptoms vanished completely for some hours. in the meantime even MDMA doesn't do it's job anymore. nonetheless, it has shown, that there IS something that can help against tourette's.
swim's friend is desperated now since his special medicine has lost its effect.
can anyone tell me if there is still a way that he can get rid of his symptoms?
but he won't take any neuroleptics like halolperidole again.
Her still wants to be just himself and not tiered so that he cant work anymore.
Is there some help??
BTW: is there a way to synthesize PERGOLID (PERMAX (R)) with uncontrolled chemicals?
SWIM's friend lives in a country where he cannot get his hands on this medicine...

I am looking forwd to reading your advices. many thanks in advance

yours truly,
mysterious

[Vitus_Verdegast]

How regularly did your friend take MDMA, what is the dose he took, and how long is he using MDMA ?

[midway]

http://pubs.acs.org/hotartcl/chemtech/96/nov/pergolide.html

it looks as if the main precursor is dihydrolysergol...hehehe if you can find that then let us know!

[Vitus_Verdegast]

I see this article has been mentioned before in

Post 294029 (missing)

(LadyEthyl: "Chems found in cannabis eases Tourette's symptoms", General Discourse)

Here's the abstract and the full PDF:

Pharmacopsychiatry (2002),35: p 57-61.
DOI:

10.1055/s-2002-25028

Medline (PMID=11951146)

Treatment of Tourette's syndrome with Delta 9-tetrahydrocannabinol (THC): a randomized crossover trial.


Muller-Vahl KR, Schneider U, Koblenz A, Jobges M, Kolbe H, Daldrup T, Emrich HM.

Department of Clinical Psychiatry and Psychotherapy, Hanover Medical School, Germany.

mueller-vahl.kirsten@mh-hannover.de

Anecdotal reports in Tourette's syndrome (TS) have suggested that marijuana (cannabis sativa) and delta-9-tetrahydrocannabinol (Delta(9)-THC), the major psychoactive ingredient of marijuana, reduce tics and associated behavioral disorders. We performed a randomized double-blind placebo-controlled crossover single-dose trial of Delta(9)-THC (5.0, 7.5 or 10.0 mg) in 12 adult TS patients. Tic severity was assessed using a self-rating scale (Tourette's syndrome Symptom List, TSSL) and examiner ratings (Shapiro Tourette's syndrome Severity Scale, Yale Global Tic Severity Scale, Tourette's syndrome Global Scale). Using the TSSL, patients also rated the severity of associated behavioral disorders. Clinical changes were correlated to maximum plasma levels of THC and its metabolites 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-THC) and 11-nor-Delta(9)-tetrahydrocannabinol-9-carboxylic acid (THC-COOH). Using the TSSL, there was a significant improvement of tics (p=0.015) and obsessive-compulsive behavior (OCB) (p = 0.041) after treatment with Delta(9)-THC compared to placebo. Examiner ratings demonstrated a significant difference for the subscore "complex motor tics" (p = 0.015) and a trend towards a significant improvement for the subscores "motor tics" (p = 0.065), "simple motor tics" (p = 0.093), and "vocal tics" (p = 0.093). No serious adverse reactions occurred. Five patients experienced mild, transient side effects. There was a significant correlation between tic improvement and maximum 11-OH-THC plasma concentration. Results obtained from this pilot study suggest that a single-dose treatment with Delta(9)-THC is effective and safe in treating tics and OCB in TS. It can be speculated that clinical effects may be caused by 11-OH-THC. A more long-term study is required to confirm these results.

Publication Types:
- Clinical Trial
- Randomized Controlled Trial


Full-text PDF:

http://www.geocities.com/eric_vornoff/pdf/thc-tourette.pdf