Possible DiPT synthesis?

[Bandil]

After reading:

https://www.thevespiary.org/rhodium/Rhodium/chemistry/dmtsyn.txt

swim was intrigued, bu the mechanism.

Ill cut right to the point:

Is it possible to do the synth: Tryptamine + acetone + [H] --> DiPT, or will the fact that its a ketone were using, cause to much sterichal hinderance?

If it is possible to do the synth, could one use the Al[Hg] as a reducing agent as in the MDMA synth?

Thanks in advance!

Regards
Peter

[terbium]

There has been some speculation that this would be a problem.

Post 194011

(Rhodium: "Re: Urushibara Catalyst for DIPT", Tryptamine Chemistry)

[Bandil]

OK, thats to bad

But what if swim boiled up a lot og IPA with some iodine and red P and distilled the product. Would that not yeild Isopropyliodide?

Then swim though of taking his IPIodide and do the usual Tryptamine + RI + cat. -> D(i)PT

Is that feasible?

Thanks
Regards Peter

[zed]

Regarding reduction with acetone.


It might be possible. In O-Chem, experimental results always trump theory. As I recall, Heinzelman was able to produce an N,N-Di-(phenylisopropyl)-methylamine, just by reducing a methamphetamine in the presence of a phenyl2propanone.

J. Am. Chem. soc. 75, 921 (1953)

(https://www.thevespiary.org/rhodium/Rhodium/pdf/2-meo-methamphetamine.pdf)

You should have this paper, regardless. It is quite interesting.

He performed his reduction using H2/Pt, which might work for you, or might not. Some data suggests there could be competing reactions.

With some tryptamine, a little acetone, some methanol, and a little Pt/H2....or Al/Hg, you could know something the rest of us don't...in just a few hours.

Please update us..................................zed