The Vespiary

The Hive => Tryptamine Chemistry => Topic started by: Damien_Thorne on July 24, 2000, 01:42:00 AM

Title: Psilocybin
Post by: Damien_Thorne on July 24, 2000, 01:42:00 AM

Call me dumb, but I was just wondering if there was a method out there which would enable me to synthecize psilocybin.  Mushrooms have always been among a favorite of my trips.

=>I am a firm believer in my Constitutional Right to the Pursuit of Happieness<=

Title: Re: Psilocybin
Post by: Rhodium on July 24, 2000, 07:10:00 AM

These are probably the best methods available:

http://rhodium.lycaeum.org/chemistry/psilocybin.html (http://rhodium.lycaeum.org/chemistry/psilocybin.html)

http://argon.ch.ic.ac.uk/ectoc/echet98/pub/039/index.htm (http://argon.ch.ic.ac.uk/ectoc/echet98/pub/039/index.htm)

http://rhodium.lycaeum.org (http://rhodium.lycaeum.org)

Title: Re: Psilocybin
Post by: Mr_Smith on July 25, 2000, 01:12:00 PM

Why synthesize when you can just grow the darn things?

Title: Re: Psilocybin
Post by: sunlight on July 26, 2000, 04:52:00 AM

Do you know what is the regioselective thallation of the 4-position and how to make it ?
I think that a good way could be attack directly DMT in 4 position and then make the acetoxy, in Psychedelic chemistry, Michael Valentine gives a rxn with H2O2 and Cu Sulfate (don't remember exactly) that yields a mixture of different OH DMT, taht can be separated with chromatography, what do you think about it ?
This regioselective thallation seem to be be better.

Title: Re: Psilocybin
Post by: Lilienthal on July 26, 2000, 11:29:00 AM

Thallium?  :o  It's extremely toxic and it's polluting the environment. Bad idea. Other 4-hydroxylation reactions have low yields or need many steps. You can find the literature references on my site:

Lilienthals References (http://www.fortunecity.com/westwood/storey/116/)

(http://www.fortunecity.com/westwood/storey/116/).

Title: Re: Psilocybin
Post by: Mr_Smith on July 27, 2000, 01:45:00 AM

Awww, but it's just not a trip unless your eyebrows fall out!!!

8)

Title: (empty)
Post by: KrZ on July 27, 2000, 02:31:00 AM

Title: Re: Psilocybin
Post by: sunlight on July 27, 2000, 02:35:00 AM

Lilienthal, don't you know the hydroxylation in Psychedelic Chemistry ? a 30 % yield seems good.