The Vespiary
The Hive => Chemistry Discourse => Topic started by: Cyrax on January 26, 2002, 08:33:00 AM
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What is the chemical structure of 3-methylfentanyl? Can someone draw me a structure formule?
Thx
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EtCo Ph
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N
Me |
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N
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Ph
something like this perhaps?
btw
this was then what now
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That is correct. It should also be noted that only (-)-cis-3-Methylfentanyl holds the extreme potency. Fentanyl is achiral, when you introduce that methyl group, you end up with 4 enantiomers.
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Isn't it amazing that 3-methylfentanyl is 30 times more potent than fentanyl ?
What about an enamine alkylation a la Stork to make the
3-methyl-4-piperidone?
Does anyone has refs. about the synthesis of 4-piperidone?
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Let me put it this way...
Attempted synthesis of 3-Methylfentanyl without a glovebox == Death