sorry that i did'nt give you enoff info on this syntheseroute,but you have to understand i'm just new here,i still have to learn.
but about the synthese:
the first route is from THIKAL page 412,
To a stirred solution of 3 g tryptamine in 30 ml IPA there was added 10g methyliodide (tryptamine/methyliodide 1:3,75).
cream colored solids appeared immediately and,after 12 h stirring st roomtemperature,these were removed by filtration,washed twice with warm IPA and airdried to constant weight.
there was obtained 1.81 g N,N,N-trimethyltryptammoniumiodide
than shulgin says that the the unreacted tryptamine can be removed on its ether insolubility.
i think the first thing to do is to concentrate the fitrate
and cool.
the second fase is to extract the second fitrate with an solvent for example ethylacetate and dilute the extract with ether to kristallize the unreacted tryptamine for re-use.
this the first possebility
the second one is to optimize the reaction.
large amound MeI,mayby other solvent.
i do know that the second route,
from otto snow:
1.6 gram tryptamine is mixed in 36 ml anhydrous ethanol.
6 gram of MeI containing 5.4 gram of anhydrous sodiumcarbonate are added to the solution and refluxed on a hot waterbath for 5 h.
the hot solution is then rapidly suction filtered,alcohol is added to the residu and heated to boiling and rapid suctionfiltered.
the filtrate is concentrated under reduced pressure.
large colorless needles o trimethyl-
beta-3-indolyl-etyl-ammonium-iodide precipitate and are suction filtered.
the solution is reduced further to crystallize more trimethyl-
beta-3-idolyl-ethyl-ammonium-iodide.
but he does not give any yield,but this one sounds much beter.
i do know that this one was first invented by a german,his name is wieland,annalen der chemie(1934) 513:1-25, but i can't find the original paper.
maybe it is worthwill to extract the unreacted tryptamine?by the way what does HI scavenging base means?