Once UPon a TimeFor several reasons, bees eventually come to realize that rarely do two rxns run identical. The main reason:
The variances are too numerous to handle a slight adjust an-E-ware without effecting one thing or another.
The most basic suggested guidelines are just that. Basic! 50 different write-ups or discussions addressing the various aspects and detailing unique variables introduced on a whim, cannot possibly list a solution for every problem created by the end user's trigger-happy slight-adjust hand.
Relux: Hindsight is 20/20 and without it we'd all bee blind.
Every determined bee has a little goofball on his shoulder that screams out "Don't Do It" at every questionable decision making fork in the road.
You shoulda listened to yours when it smacked ya upside the head with it's pitchfork and said that the RP might be questionable since it got gangbanged during the last rxn.
Always remember the saying:
"If there is the slightest iota of doubt concerning any of the reactants effectiveness/cleanliness, don't proceed until the visioncorrecting goofball stops pokin yer ass
Now...a few concerns.
What's UP with tweekin the ratio in order to snag the goodz sooner?
Two things determine complete reduction.
HI concentration, while it plays a large role, isn't a first choice. Surely that little goofball chimed in at that thought-provoking junction...ehh?
Temp and hydration level can be tweeked in order to shorten cooktime at a price.
Three prices actually.
Purity, yield, and quality.
They all deal with the "degree of doneness" factor which can be deceptive and misleading if only considering the "Success versus Failure" scale of calculation.
All three are governed by cooktime and directly associated with reactant concentration, rxn rate/heat of rxn laws, collision theories, second order rxns...etc...etc.
•Purity, as in substituent impurity by-products initially created in-situ, in HI rxns, and found to be present in product considered to bee done by popular standard measures when pulled prematurely without allowing the rxn to fully run it's course.
•Yield, as in percentage of unreacted vs fully reduced....minus the weight of impurities.
•Quality, as in the sum of all factors considered and exactly where, when, and how many compromising tweeks were employed before the shoulder dwelling goofball threw down his pitchfork in frustration screaming "I GIVE UP!", just to see what kind of rxn he could get out of ya....
And They AWE Lived Happily Ever After