The Hive => Novel Discourse => Topic started by: Vibrating_Lights on June 03, 2002, 07:12:00 AM
Title: Methoxamine
Post by: Vibrating_Lights on June 03, 2002, 07:12:00 AM
Looking at the chemical structure of Methoxamine is it concieveable then that the 2-amino-1-(2,5dimethoxyphenyl)-1-propanol could be reduced via HI to the amphetamine. or any of the various ephedrine pathways. VL_
Title: I believe this has been brought up before, and it ...
Post by: PrimoPyro on June 03, 2002, 07:16:00 AM
I believe this has been brought up before, and it was concluded that, at least with the HI reduction, the methoxy groups would be torn to pieces.
Title: How about this? Post 178931 us 2243295
Post by: PolytheneSam on June 03, 2002, 07:29:00 AM
How about this?
Post 178931 (missing)
(PolytheneSam: "PPA --> meth this easy?", Chemistry Discourse)
http://www.geocities.com/dritte123/PSPF.html The hardest thing to explain is the obvious
Title: things from methoxamine
Post by: obia on June 05, 2002, 01:11:00 AM
should reduce with cat h2 and a small amount of phosphoric acid to 2,5 dma. the phosphoric acid shouldn't cleave the meos. it could be brominated then oxidised to dob (cath)inone. there might be a problem with the hydroxy group being chewed up. I would guess that dob-inone would be have a few unwanted cardiovascular effects though
or it could be turned into an aminorex derivative, possibly with a halo 4 substituent added in prior to ring closure.
I guess though that economics dictate it isn't going to be a good starting material.