Post 475109 (https://www.thevespiary.org/talk/index.php?topic=11892.msg47510900#msg47510900)
(Lego: "Amphetamines/PEAs w/o benzaldehyde or nitroethane", Novel Discourse), where they bromomethylate benzene in 86,5% yield with a VERY easy procedure. It's almost a shake'n'bake procedure.Post 360218 (missing)
(Rhodium: "3,4-Methylenedioxy-1-bromobenzene Synthesis", Newbee Forum), the chief says that benzodioxole is brominated in super high yields(91%) to 3,4-methylenedioxy-bromobenzene. Obviously this means that the methylendioxy bridge activates the correct sites on the aromatic ring. The only problems i can think of are the following:Post 475109 (https://www.thevespiary.org/talk/index.php?topic=11892.msg47510900#msg47510900)
(Lego: "Amphetamines/PEAs w/o benzaldehyde or nitroethane", Novel Discourse), the same thing should apply. That is, that the group would activate the o,p-position for further bromomethylation, yet this does not happen when the reaction is run carefully. Any ideas if this would work or not?Post 475109 (https://www.thevespiary.org/talk/index.php?topic=11892.msg47510900#msg47510900)
(Lego: "Amphetamines/PEAs w/o benzaldehyde or nitroethane", Novel Discourse)(the one w/o HBr) to yield 3,4-methylenedioxy-bromomethylbenzene.here (https://www.thevespiary.org/rhodium/Rhodium/chemistry/phenylacetone.html#grignard)
(https://www.thevespiary.org/rhodium/Rhodium/chemistry/phenylacetone.html#grignard)here (https://www.thevespiary.org/rhodium/Rhodium/chemistry/phenylacetone.html#grignard)
(https://www.thevespiary.org/rhodium/Rhodium/chemistry/phenylacetone.html#grignard) under anhydrous conditions.Regioselective Bromination of Aromatics Using KBr/Oxone (https://www.thevespiary.org/rhodium/Rhodium/chemistry/oxone.aromatic.bromination.html)
(https://www.thevespiary.org/rhodium/Rhodium/chemistry/oxone.aromatic.bromination.html) orPost 472828 (https://www.thevespiary.org/talk/index.php?topic=11473.msg47282800#msg47282800)
(Nicodem: "2,5-Dimethoxybromobenzene Chloromethylation", Novel Discourse)Post 464635 (missing)
(Lego: "P2P from bromobenzene/CuI/Acetylacetone", Methods Discourse)https://www.thevespiary.org/rhodium/Rhodium/chemistry/alhg.oxime.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/alhg.oxime.html)
https://www.thevespiary.org/rhodium/Rhodium/chemistry/oxime.txt (https://www.thevespiary.org/rhodium/Rhodium/chemistry/oxime.txt)
https://www.thevespiary.org/rhodium/Rhodium/chemistry/redamin.zirconium.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/redamin.zirconium.html)
https://www.thevespiary.org/rhodium/Rhodium/chemistry/oxime2amine.zn-cu.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/oxime2amine.zn-cu.html)
https://www.thevespiary.org/rhodium/Rhodium/chemistry/mdaoxime.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/mdaoxime.html)
Post 470658 (https://www.thevespiary.org/talk/index.php?topic=11897.msg47065800#msg47065800)
(psyloxy: "oxime reductions w/ Ca and Pd/C NH4COOH", Novel Discourse)Post 476580 (https://www.thevespiary.org/talk/index.php?topic=9272.msg47658000#msg47658000)
(Chromic: "Al/Hg on ketoximes", Methods Discourse)Post 477266 (missing)
(Lego: "Reduction of oximes with zinc/ammonium formate", Novel Discourse)Post 442691 (missing)
(Lego: "Reduction of an aldoxime with Zn/HCl", Novel Discourse)Post 413177 (https://www.thevespiary.org/talk/index.php?topic=11788.msg41317700#msg41317700)
(Lego: "Reduction of ketoximes with Zn/NH3", Novel Discourse)For phenethylamines this method is great, if instead of acetonitrile sodium formate is used.
Huh? This makes no sense to me... Could you clarify?
Lego meant these articles on your page:
Aldehydes from Grignard reagents with formic acid (https://www.thevespiary.org/rhodium/Rhodium/chemistry/grignard.formic.html)
(https://www.thevespiary.org/rhodium/Rhodium/chemistry/grignard.formic.html)Is there any particular reason why the method you mention is preferrable over the one I suggested when it came to MDP2P? Do you think the yields will be superior by this method? The only drawback i can see is that you can't work with grignard reactions with to much THC in the blood ;D
Most bees have serious troubles with Grignard reactions, so Lego considers the bake&fry-method with the acetylacetone to bee superior for this substrate. Your method will work for sure, too, although Lego is not really sure if the methylendioxy group will survive the concentrated sulfuric acid completely.
THC will bee superior for Grignard reactions as the addition has to bee done carefully and slowly, much better than meth ;)