maybe little offtopic, but what about this
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At the first place I¨d like to say, that I am very comprehent that on the Hive there is several (nearly hundred
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) of threads on pheny, but in no of these there is no complete steps .This thread is to be something such as racemate version of all those pheny threads
![Smiley :)](https://thevespiary.org/talk/Smileys/default/smiley.gif)
I would like to ask the huge scientists on Hive, if is possible this "substitution":
- according master KRZ and his catalytic hydrogenation (via Rylander) of l-phenylalanine into dextroamph. via Pt/C 5% catalyst, glacial acetic acid and anhydride Ethanol (as a solvent for reaction) in hydrogenator at 6 atmospheres (90 psi) - if is possible to make this reaction without using pressurized hydrogen vessel , but , as a substitude use some kind of hydrogen donor (i dont know what king exactly)
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is possibility to use some of these hydrogen donors - ammonium formate , cyclohexane , hydrazine (not much good) , formic acid , cyclohexadiene , phosphinic acid , sodium hypophosphite , LiAlH4 , NaBH4 or LiBH4 (i dont know which are basis or acidy)
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I suppose also that , if this way is possible , the best hydrogen donor should be formic acid ,
cause it reacts via this: H(C=O)OH (catalyst)--> O=(C=O) + nascent hydrogen (H2) (gives hydrogen and produces CO2).
- the second "main" question I have to all math-profesors and math-scientist on Hive is this:
is possible to provide the reaction (again) via KRZ (l-pheny to dextroamph.) with using stronger catalyst than Pt/C 5% - something for ex. as Pd/C 10 %
(maybe for the prize of little lowered 'ring reduction' - and lowered yield) ?
if yes, so there is my (very apprentice) idea to make reaction in MW oven (under reflux) on low irradiation (and maybe on modulated irradiation - but this thing is another big question) and as a hydrogen source use some kind of Gas Hydrogen generator (for example by Mr. Drone #342) and bubble the hydrogen through the
'reacting' solution (same as use KRZ) under very good stirring and under MW irradiation (as above). The temperature sholdnt rise above 45 - 50 C degrees ,
so the MW irradiation is to be very low (defrosting stage ? - it is about 30% and is modulated) and so there will be no evaporation of ethanol (solvent) or rather no evap. at all.
Is this pioneer idea possible ? How much time should the reaction take ? Or is the better way to use some kind of hydrogen donor (if some exist for this
type of reaction) ? Or this thread is bullshit (excuse for this word) and the only way is to use pressure vessel
![Huh ???](https://thevespiary.org/talk/Smileys/default/huh.gif)
thank you for your reply
Perpeetuum (goes forever and forever and forever and ....)
P.S: Please, don't blame me for all these words above, I'm just appretice in chemia.