The Hive > Tryptamine Chemistry

AMT in the MW oven

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hest:
500mg indole-3-aldehyde was mixed with 1g nitromethane and 50mg amm.acetate. The mixture was nuked with 150W for 2min, and then rextalised from methanol.
Yeald: >90%
TLC (40% EtOAc in Hep.) 0,41

hest:
now also done in 10g scale. 5min MW @ 150W. Product filtered off from the cold nitroethanesolution an rextalised from methanol (still drying)

Rhodium:
Doesn't the nitromethane boil off when being nuked for so long periods of time?

Did you use any mw energy absorber (like a beaker of water), or a mw-inert heatsink for the reaction flask (like alumina)?

hest:
I have made my own mw-oven. Drilled a 6cm hole at the top and mounted a 30cm long copper-pipe (soldered to the inner chamber). as long as the pipe's diam. is smaller than ½ the wave length and longer than 1 wave length nothing leaks out (the wave length of mw oven is 13,5cm). Into this pipe is a glass tube with a condenser over the oven.
No mw energy absorber

Rhodium:
Such modifications make the setup work great, I've heard. However, please do include such essential details the next time you are posting anything mw-related...  ::)

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