The Hive => Novel Discourse => Topic started by: Anansi on July 29, 2002, 09:51:00 AM
Title: 4-Methyl Fentanyl
Post by: Anansi on July 29, 2002, 09:51:00 AM
There was some interest in the .PDF Journal Article I posted regarding synthesis & pharmacology of Longer Acting Fentanyl Analogues.
I also have the .PDF for a journal article regarding the synthesis & pharmacology of 4-Methyl Fentanyl. This analogue is approximately 3x the potency of Fentanyl and has significantly better confidence limits. The journal article is by I.V. Micovic et al. - the same group who published the article about 2,3-secofentanyl available at Rhodium's site.
In this article this article they use a different method to the more common N-alkylation of 4-piperidone, formation of imine derivative of N-alkylpiperidone followed by reduction of imine derivative etc. The method presented is also suitable for the synthesis of other 4-substituted fentanyl derivatives, which range between 2x and 30x the activity of Fentanyl.
I don't have the ability to put the .PDF online, but if bees express some interest in this article I can email it to Rhodium, who can make it available.
...Anansi
Title: re: 4-Methyl Fentanyl article
Post by: ChemisTris on July 29, 2002, 09:56:00 AM
What is the title of the paper, and what journal does it appear in? Thanks :) Got democracy?
Title: 4-methyl fentanyl
Post by: blondie on July 29, 2002, 11:06:00 AM
Anansi, blondie would be interested in the pdf, i think it would also make a good addition to Rhodium's archive.
Title: The title is: 'The synthesis and preliminary ...
Post by: Cyrax on July 29, 2002, 05:56:00 PM
The title is: 'The synthesis and preliminary pharmacological evaluation of 4-methyl fentanyl' and the article appeared in 'Bioorganic & Medicinal Chemistry Letters (2000) vol 10 p 2011 - 2014'
Title: 4-Methyl-fentanyl
Post by: Rhodium on July 29, 2002, 09:50:00 PM