Would it be possible to chlorinate 2,5-dimethoxyamphetamine (t o yield DOC) with HCl in tert-butyl hydroperoxide as discussed in the following document:
https://www.thevespiary.org/rhodium/Rhodium/chemistry/halosuccinimide.txt (https://www.thevespiary.org/rhodium/Rhodium/chemistry/halosuccinimide.txt)
?
I've searched all day, and the alternatives doesn't look that hot, rather avoid liquid chlorine and perchloric acid (NCS-route seemed like a simple procedure otherwise) if I could. :D
How 'bout UTFSE a bit and look for the alternatives used to make 2C-C (the direct homolog of DOC). I posted something about just that about a year ago. It can't get much easier really.
You posted about the Oxone/KCl procedure a while ago:
Post 384324 (https://www.thevespiary.org/talk/index.php?topic=11530.msg38432400#msg38432400)
(Barium: "A little 2C-C perhaps", Novel Discourse)Did you ever boost your yields?
I lost interest in that family once I successfully made them. :P
No oxone halogenation has been performed since that one. If I ever go back to them again I am more interested in making them without having to go through 2C-H or DMA.
I want challenges, damnit! ;)
Thank you very much!
Just one question, in you're writeup I suppose you forgot to mention the addition of KCl? Just dissolve KCl and 2,5-DMA in H2O/MeOH and then addition of oxone as in the 2C-I writeup?
I have never been succesful in chlorination or iodination of 2C-H and 2,5-DMA with oxone and KCl (or KI). On the other hand, I have been succesful in using the same method for bromination of anisole.
I did not forget to mention the KCl addition. The chloride source was the 2C-H*HCl. It acts as amine source and chloride source at the same time.