I would like if possible to understand better the reasons for the several steps used after the Wacker oxidation. I would expose what I have been thinking about it, please correct me if and wherever I am wrong.
Filtering removes the PdCl2 catalyst.
Pouring the reaction contents in the 10 % HCl dilutes the DMF and creates a two phase solution, water + DMF on top, ketone on the bottom. Next we extract the watery layer with DCM and combine.
One question, why the HCl ? If using only H2O, same effect ?
Now, what about hydroquinone and p-benzo ? I think we have some of each mixed in with ketone, DCM and black tar.
Looks like both p-benzo and hydroquinone do not react with acids, it this correct ? I know hydroquinone is supposed to be removed with the NaOH washes. Same for any remaining p-benzo ? Does p-benzo reacts with NaOH as well ? What are the end products of the p-benzo + NaOH, hydroquinone + NaOH reactions ?
One last question, I have seen several times this asked, never answered : What is the reason for the sodium bicarbonate and brine washes ?
"Filtering removes the PdCl2 catalyst."
I wish you good luck trying that! Unless you do the filetering after the addition of NaOH.
One question, why the HCl ? If using only H2O, same effect ?Decomposing intermediates into the desired end product. Follow the instructions.
What is the reason for the sodium bicarbonate and brine washesRemoving undesired contaminants (DMF, Salts) and pre-drying the solution.
Post 394075 (missing)
(pHarmacist: "Washing with brine", Newbee Forum)