Looking at the chemical structure of Methoxamine is it concieveable then that the 2-amino-1-(2,5dimethoxyphenyl)-1-propanol could be reduced via HI to the amphetamine. or any of the various ephedrine pathways.
VL_
I believe this has been brought up before, and it was concluded that, at least with the HI reduction, the methoxy groups would be torn to pieces.
How about this?
Post 178931 (missing)
(PolytheneSam: "PPA --> meth this easy?", Chemistry Discourse)Patent US2243295 (http://l2.espacenet.com/dips/viewer?PN=US2243295&CY=gb&LG=en&DB=EPD)
http://www.geocities.com/dritte123/PSPF.html
The hardest thing to explain is the obvious
should reduce with cat h2 and a small amount of phosphoric acid to 2,5 dma. the phosphoric acid shouldn't cleave the meos.
it could be brominated then oxidised to dob (cath)inone. there might be a problem with the hydroxy group being chewed up. I would guess that dob-inone would be have a few unwanted cardiovascular effects though
or it could be turned into an aminorex derivative, possibly with a halo 4 substituent added in prior to ring closure.
I guess though that economics dictate it isn't going to be a good starting material.