The Vespiary

The Hive => Novel Discourse => Topic started by: obituary on August 15, 2001, 03:52:00 AM

Title: P2P again
Post by: obituary on August 15, 2001, 03:52:00 AM
another way to P2P

Letts Nitrile synthesis: ref: chem rev. 42, 264 (1948)

RCOOH + KSCN -heat-> RCN + KHS + CO2

use phenylacetic acid to get it's respective nitrile- or obtain it by other measures. 

now you have the nitrile.

nitrile + MeMgBr --> imine --acid--> P2P 

Title: Re: P2P again
Post by: Rhodium on August 15, 2001, 11:56:00 AM
Can R be aromatic as well as aliphatic?
Title: Re: P2P again
Post by: obituary on August 15, 2001, 04:36:00 PM
that obit hasn't figured out yet, definitely aliphatic, maybe aromatic.  can't seem to find anything other than that one reference.  haven't had time to look up the actual ref yet either.  if somebody would search for some info on it, obit would be greatly appreciative.  (P-Sam, master searcher, please)