One doesn't have to think hard if one had a look at the 'P2Pol from acetaldehyd' thread to come to the following thought:
Tryptamine or Tryptophan --> Indole-3-AcH
Indole-3-AcH NH3 --> Indole-3-AcH-imine
Indole-3-AcH-imine -MeMgI-> AMT or -EtMgI-> AET
for 5-MeO-AMT one obviously has to start with 5-MeO-I3ACH.
So what do you think, could this work ??
/jesus
I believe the easiest way would be to formylate the indole to the indole-3-aldehyde, and then react it with nitroethane/nitropropane to get the nitroalkene, then reduce it with LAH or similar.
http://rhodium.lycaeum.org (http://rhodium.lycaeum.org)
Not everyone has easy access to Indole, POCl3, NMF, EtNO2/PrNO2 and LAH.
But would it still work even if it's not your favorite route ?
--psyloxy--
The indoleacetaldehyde is very polymerization-prone, and I believe the imine would be too.
http://rhodium.lycaeum.org (http://rhodium.lycaeum.org)