Post 28888 (missing)
(zooligan: "Re: 2cb For the Chemistry Impared", Newbee Forum) by Zooligan is the only mention of brominating the HCl salt. All other refs SWIM has seen brominate the freebase of 2CH. So, must the 2CH be converted into it's freebase prior to brominating? If not, is there any known yield benefit from using the freebase over the acid salt?Iff the HCl salt is soluble in the AcOH (I don't think it is, the HBr of 2-cb is not) then it's posible,
Is there any reason why the 2CH couldn't be dissolved in a minimal amount of H2O and added to the HOAc/Br2? SWIM understands that the 2CB HBr is soluble in H2O and won't crystalize upon formation, but is there any reason why the post-rxn mixture couldn't be washed with DCM to remove excess bromine and then acid/based as usual? Perhaps the only drawback being extra NaOH needed to neutralize the HOAc.
but why bother, the Shulgin way works greath.
SWIM has no doubt that it does, but in these dreams the 2CH is already in the HCl salt form (it had to be stored for an extended period of time, forming the HCl salt seemed the most convienient way for this). If basifying/extracting/removing solvent pior to brominating can be skipped, that would be nice.
SpicyBrown