The Hive => Chemistry Discourse => Topic started by: mysterious on February 26, 2003, 04:53:00 AM
Title: proscaline
Post by: mysterious on February 26, 2003, 04:53:00 AM
hi all friends!!
anyone every tried proscaline (p)?? i read of it in shulgins book!! do you know if this substance can be made of any uncontrolled substances??
anyone who tried it: how would you describe the effects??
nice greetings!! mysterious
Title: Route
Post by: Barium on February 26, 2003, 05:46:00 AM
Syringaldehyde is alkylated with propyl iodide to 3,5-dimethoxy-4-propoxybenzaldehyde, the benzaldehyde is reacted with a chloroacetic acid ester in a Darzens condensation to give (3,5-dimethoxy-4-propoxyphenyl)acetaldehyde. This acetaldehyde can be reductively aminated with ammonia and Raney nickel, or the aldoxime formed with hydroxylamine which is then reduced to the amine proscaline (3,5-dimethoxy-4-propoxyphenethylamine). All reagents here are pretty unwatched.
Title: syringaldehyde from vanillin
Post by: Rhodium on February 26, 2003, 04:05:00 PM
Title: Questions, questions.
Post by: Antoncho on February 26, 2003, 10:14:00 PM
the benzaldehyde is reacted with a chloroacetic acid ester in a Darzens condensation to give (3,5-dimethoxy-4-propoxyphenyl)acetaldehyde. This acetaldehyde can be reductively aminated with ammonia and Raney nickel
Mmmmm, can you elaborate on that? Ever done this? I mean, you once wrote you were going to, but thus far all i read from you was on P2Ps via chloropropionates. Maybee, i should UTFSE better?
I always had a notion of this method as of somehow untrustworthy since those acetaldehydes would bee very hard to keep from polymerisation.... no?
Antoncho
Title: Reductive amination of phenylacetaldehydes
Post by: Rhodium on February 26, 2003, 10:33:00 PM