The Vespiary

The Hive => Chemistry Discourse => Topic started by: Bwiti on December 16, 2002, 04:42:00 AM

Title: Impurity -> Grignard?
Post by: Bwiti on December 16, 2002, 04:42:00 AM
I dried my THF over NaOH for about a week, then decanted it off into a dry bottle with a teflon screw-cap. After doing this, I noticed that a small amount of NaOH particles came over with it. Will this adversely effect a Grignard rxn?

Love my country, fear my government.
Title: In this case, hydroxide is an acid
Post by: Rhodium on December 16, 2002, 04:51:00 AM
As OH- is way more acidic than R-, any hydroxide ions in the THF will consume one equivalent of grignard reagent. I suggest that you distill it before use, or you might get problems starting the reaction (unless you are making MeMgI or any other very reactive grignard).
Title: bromobenzene
Post by: Bwiti on December 16, 2002, 06:19:00 AM
I'm planning on using bromobenzene, so I'll have to distill. Thanks for the heads-up. :)

Love my country, fear my government.