The Vespiary

The Hive => Chemistry Discourse => Topic started by: lastchance on February 26, 2004, 10:31:00 PM

Title: Converting heliotropin to isosafrole or safrole
Post by: lastchance on February 26, 2004, 10:31:00 PM
Is there any way to to this?  Any responses would be appreciated.
Title: Wittig
Post by: Kinetic on February 26, 2004, 10:50:00 PM
Yes. You musn't have looked very hard. There are posts here specifically on the use of the Wittig reaction to convert piperonal (heliotropin) to isosafrole. There is also at least one page on Rhodium's site dedicated to the same.

If you're really lazy click here (https://www.thevespiary.org/rhodium/Rhodium/chemistry/isosafrole.piperonal.html)

(https://www.thevespiary.org/rhodium/Rhodium/chemistry/isosafrole.piperonal.html).
Title: It's possible but probably not worth it as i...
Post by: cublium on February 27, 2004, 07:41:00 AM
It's possible but probably not worth it as i can see from link above.Convert to nitropropene and reduce that to something or convert to ketone.
Title: I really don't see what this thread is doing...
Post by: GC_MS on February 27, 2004, 08:05:00 AM
I really don't see what this thread is doing in the Serious Chemistry dpt.... If you can get a hold on acetic anhydride, a practical and in the scientific literature well described procedure would be via the Perkin reaction.