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The Vespiary

The Hive => Chemistry Discourse => Topic started by: blessed on May 26, 2003, 04:36:00 PM

Title: removal of TBAF?
Post by: blessed on May 26, 2003, 04:36:00 PM
Is there an easy way to remove tetrabutylammoniumfluoride (TBAF) or other TBA-salts from your rxn-product, in cases where recrystallisation won´t work (other than ion-exchange chromatography)??
This TBA-stuff sticks to my product all the way through extracting, washing, and more than one flash-silicagel-chromatography!
Title: Which product?
Post by: Lilienthal on May 26, 2003, 09:41:00 PM
Which product?
Title: distillation?
Post by: yellium on May 26, 2003, 10:09:00 PM
distillation?
Title: produkt = 1,2-Biphenylacetylene
Post by: blessed on May 26, 2003, 10:55:00 PM
products = different 1,2-Biphenylacetylenes from two succeesing Sonogashira-rxn with TMS-Acetylen and aromatic iodides
TBAF was used for removal of TMS-Group after first Sonogashira-rxn(destillation seems unprobable, products are crystalline solids)
Title: Silica gel should remove it.
Post by: slappy on June 20, 2003, 12:02:00 AM
Silica gel should remove it. Use the good 200mesh merck stuff. If that doesn't work, (I couldn't tell you why not)
use cation exchange resin.
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