The Vespiary

The Hive => Chemistry Discourse => Topic started by: Vibrating_Lights on February 09, 2003, 12:42:00 PM

Title: Benzyl alcohol to d-methamphetamine
Post by: Vibrating_Lights on February 09, 2003, 12:42:00 PM

How would one go from Benzyl alcohol to P2P
VL_

Title: help
Post by: Vibrating_Lights on February 09, 2003, 12:57:00 PM

Can someone scan This ref for me


benzyl alcohols --> benzaldehydes

synthetic communications, 2001 31(9), 1389-1397
"SILICA GEL SUPPORTED JONES REAGENT (SJR):
A SIMPLE AND EFFICIENT REAGENT FOR OXIDATION
OF BENZYL ALCOHOLS TO BENZALDEHYDES"
mohammed hashmat ali, candace j wiggin
abstract: Jones reagent supported on silica gel (SJR) has been used for
oxidation of benzyl alcohols to the corresponding benzaldehydes in high yields
utilizing organic solvent. This newly developed reagent is easy to prepare and
use. SJR is also safer than the traditional Jones reagent.

Benzylalcohol -> Benzylaldehyde -> Phenyl2nitropropene -> Phenyl-2-propanone ->  DL methamphatamine

To seperate the isomers could one wash the toulene/dlmeth with l-ascoibic acid then gas gas the d out with Hcl.

And yes nitroethane is available in any ammount OTC
VL_

Title: Suggestion
Post by: Kinetic on February 09, 2003, 01:20:00 PM

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How would one go from Benzyl alcohol to P2P

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You've answered your own question!

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Benzylalcohol -> Benzylaldehyde -> Phenyl2nitropropene -> Phenyl-2-propanone

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Every step of which will give plenty of hits in TFSE, and also on Rhodium's site.

Title: Synlett 2041-2042 (2002)
Post by: Vibrating_Lights on February 09, 2003, 01:55:00 PM

Typical procedure: A mixture of 557 mg of benzyl alcohol, 0.15 mL of HBr (48%) and 5 mL of DMSO was stirred in an oil bath at 100 ºC. TLC (petroleum ether/diethyl ether, 1:1) was used to indicate the completion of the reaction (3 h). To the reaction mixture were added 5 mL of brine followed by extraction with 30 mL of diethyl ether. The ether layer was washed with brine (4x5 mL). Evaporation of ether and subsequent bulb to bulb distillation produced 530 mg of benzaldehyde in 95% yield.

How about this??

NaBr is dissolved in H2O then mixed with the Dmso then an euqalmolar ammount of H2SO4 is added to produce the HBr.  Then the alcohol is added and held at 100.c  For 4 hrs.  Would having the NaSO4 in the mix hurt the rxn????
Vl_ 

Title: Silica-Supported Jones Reagent
Post by: Rhodium on February 09, 2003, 02:28:00 PM

Okay, here you go:

https://www.thevespiary.org/rhodium/Rhodium/chemistry/alcohol2aldehyde.sjr.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/alcohol2aldehyde.sjr.html)

Title: Would you, please...
Post by: Antoncho on February 09, 2003, 10:54:00 PM

VL, i'm asking you nicely - would you please quit posting crap into Chemistry Discourse, huh? It's barely readable lately beecause of people like you.

All of this has been discussed a zillion times bee4.

Furthermore, the posts that contain QUESTIONS should bee supplied w/the relevant DATA; all imaginable data you could've possibly found WITHOUT help of the bees! Otherwise you're just trying to waste other people's time on what you could've done by yourself.



Antoncho

Title: Furthermore,
Post by: blasephilomath on February 11, 2003, 10:50:00 AM

Anyone can buy benzaldehyde at the grocery store if they know where to look.