Some Recent Applications of (https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000442506-file_lwwo.gif)-Amino Nitrile ChemistyChem. Soc. Rev., 29 (5), 359-373 (2000) (http://www.rsc.org/CFmuscat/intermediate_abstract.cfm?FURL=/ej/CS/2000/a908290e.PDF&TYP=)
(http://www.rsc.org/CFmuscat/intermediate_abstract.cfm?FURL=/ej/CS/2000/a908290e.PDF&TYP=)
DOI:
10.1039/a908290e (http://dx.doi.org/10.1039/a908290e)
Abstract Bifunctional
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000442506-file_lwwo.gif)-amino nitriles are not only versatile intermediates in organic synthesis but also exhibit a valuable dual reactivity, which has been utilized in a broad range of synthetic applications. This review highlights recent developments in the chemistry of
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000442506-file_lwwo.gif)-amino nitriles, including asymmetric synthesis of
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000442506-file_lwwo.gif)-amino acids via Strecker reactions using chiral auxiliaries and catalysts,
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000442506-file_lwwo.gif)-amino nitriles as masked iminium ion equivalents in cationic reactions and the synthesis of natural products and heterocycles, and
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000442506-file_lwwo.gif)-metallation to provide nucleophilic acyl anion equivalents and applications to asymmetric Umpolung reactions.
Were you thinking of any specific applications of this substance class, or did you just want to share the free review?
In the (Scheme 26 )Summary of reactions of lithiated a-amino nitriles.
Notice that the production of P2P ketone and diketones in the reaction with lithiated amino nitriles, that cought my eye and could be exploited say using a cheap OTC Phenylalanine amino acid.......java
