Print Page - Compilation on GHB/GBL

Title: Compilation on GHB/GBL
Post by: Aurelius on June 13, 2003, 09:20:00 AM

Compilation for GBL and GHB

Preparation of salts of GHB/GBL

https://www.thevespiary.org/rhodium/Rhodium/chemistry/ghb-r-us.txt (https://www.thevespiary.org/rhodium/Rhodium/chemistry/ghb-r-us.txt)

GABA to GHB

Post 394630 (missing)

(Chromic: "Success making GBL!", Chemistry Discourse)

Post 364288 (https://www.thevespiary.org/talk/index.php?topic=6911.msg36428800#msg36428800)

(Rhodium: "GABA -> GBL + GHB", Chemistry Discourse)
Comment on distillation of GBL from this particular reaction mixture:

Post 375796 (https://www.thevespiary.org/talk/index.php?topic=6911.msg37579600#msg37579600)

(Rhodium: "If you acidify the solution slightly (pH 4-6), ...", Chemistry Discourse)
Physical Properties of GABA:

Post 375570 (missing)

(Chromic: "Question your GABA", Chemistry Discourse)
Note on the Formation of Nitrosamines in this Rxn:

Post 378237 (missing)

(fierceness: "nitrosamines", Chemistry Discourse)

Post 412468 (missing)

(hCiLdOdUeDn: "Nitrosamine decontamination", Chemistry Discourse)

GBL, 1,4-butanediol, and THF

Post 414046 (missing)

(roger2003: "German Dissertation about industrial scale...", Chemistry Discourse) (in german)

https://www.thevespiary.org/rhodium/Rhodium/chemistry/gbl.synthesis.microgram.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/gbl.synthesis.microgram.html)

GBL from 1,3-Propanediol

Post 489813 (https://www.thevespiary.org/talk/index.php?topic=9148.msg48981300#msg48981300)

(Rhodium: "GBL synthesis starting from 1,3-Propanediol", Methods Discourse)

GBL/GHB from 1,4-butanediol
Oxid. with NaOCl and RuCl2

Post 444525 (missing)

(Vitus_Verdegast: "I'm in a typ-o-maniacal mood today ;-)", Methods Discourse)
Oxidation with Permanganate:

Post 243620 (https://www.thevespiary.org/talk/index.php?topic=11867.msg24362000#msg24362000)

(foxy2: "Re: Easy Oxidation of THF to GBL", Novel Discourse)
Oxid. to GBL with various reagents

Post 441399 (missing)

(Rhodium: "1,4-BD -> GBL (76%) w/Trichloroisocyanuric Acid", Methods Discourse)

Post 441437 (https://www.thevespiary.org/talk/index.php?topic=8929.msg44143700#msg44143700)

(Rhodium: "Chem. Abs. 130:24638.", Methods Discourse)

Post 441438 (https://www.thevespiary.org/talk/index.php?topic=8929.msg44143800#msg44143800)

(Rhodium: "Chem. Abs. 130:313445", Methods Discourse)

Post 442866 (https://www.thevespiary.org/talk/index.php?topic=8929.msg44286600#msg44286600)

(Rhodium: "1,4-BD -> GBL (92%) using NaBrO2/Alumina", Methods Discourse) (typed version next)

Post 443378 (https://www.thevespiary.org/talk/index.php?topic=8929.msg44337800#msg44337800)

(Vitus_Verdegast: "article typed up", Methods Discourse)
Reaction with N-Haloamides:

Post 246415 (https://www.thevespiary.org/talk/index.php?topic=11867.msg24641500#msg24641500)

(Rhodium: "Re: Easy Oxidation of THF to GBL", Novel Discourse)
Dehydrogenation of the Diol:

https://www.thevespiary.org/rhodium/Rhodium/chemistry/bd2gbl.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/bd2gbl.html)

Post 441834 (https://www.thevespiary.org/talk/index.php?topic=8929.msg44183400#msg44183400)

(Rhodium: "1,4-Butanediol to gamma-Butyrolactone in French", Methods Discourse) (in french, same as next link)

Post 441898 (missing)

(GC_MS: "1,4-Butanediol to gamma-Butyrolactone in English", Methods Discourse)(in english)

Post 449422 (https://www.thevespiary.org/talk/index.php?topic=6952.msg44942200#msg44942200)

(Rhodium: "Maybe activation by pre-reduction is needed?", Chemistry Discourse) (dehydrogenation catalyst information/idea)
Oxid. with Hypohalite:

https://www.thevespiary.org/rhodium/Rhodium/pdf/bd2gbl.pdf (https://www.thevespiary.org/rhodium/Rhodium/pdf/bd2gbl.pdf)

Other References for Use of Diol:

https://www.thevespiary.org/rhodium/Rhodium/chemistry/bdo2gbl.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/bdo2gbl.html)

Synthesis of 1,4-butanediol

Patent US6486367 (http://l2.espacenet.com/dips/viewer?PN=US6486367&CY=gb&LG=en&DB=EPD)

Patent US6100410 (http://l2.espacenet.com/dips/viewer?PN=US6100410&CY=gb&LG=en&DB=EPD)

Post 471608 (https://www.thevespiary.org/talk/index.php?topic=11840.msg47160800#msg47160800)

(Rhodium: "Maleic Anhydride + BDO -Zn/Cu-> 2 GBL", Novel Discourse)

GBL/GHB from THF
Oxidation with Bromate:

Post 214379 (missing)

(foxy2: "Re: New(?) angle on THF > GBL", Chemistry Discourse)

https://www.thevespiary.org/rhodium/Rhodium/pdf/thf2gbl.pdf (https://www.thevespiary.org/rhodium/Rhodium/pdf/thf2gbl.pdf)

(includes mechanism)

Post 242315 (https://www.thevespiary.org/talk/index.php?topic=11867.msg24231500#msg24231500)

(Rhodium: "Easy Oxidation of THF to GBL", Novel Discourse)

Post 243615 (https://www.thevespiary.org/talk/index.php?topic=11867.msg24361500#msg24361500)

(foxy2: "a multi-purpose oxidant", Novel Discourse)
Experience with ox. bromate/H₂O₂

Post 474583 (https://www.thevespiary.org/talk/index.php?topic=9943.msg47458300#msg47458300)

(Beeswax: "Modification: Bromate oxidation THF -> GBL", Methods Discourse)

Oxid. with Trichloroisocyanuric acid

Post 444004 (missing)

(Aurelius: "Trichloroisocyanuric acid, ethers to esters", Methods Discourse)

Post 446457 (missing)

(Aurelius: "Ether Oxid. Tet. 27, 2671-2674, (1971) THF-GBL", Methods Discourse)

Post 340852 (https://www.thevespiary.org/talk/index.php?topic=11567.msg34085200#msg34085200)

(Captain_Mission: "GBL from THF using trichloroisocyanuric acid", Novel Discourse)
Oxidation with Permanganate:

Post 243620 (https://www.thevespiary.org/talk/index.php?topic=11867.msg24362000#msg24362000)

(foxy2: "Re: Easy Oxidation of THF to GBL", Novel Discourse)

https://www.thevespiary.org/rhodium/Rhodium/pdf/solventfree.kmno4.oxidation.pdf (https://www.thevespiary.org/rhodium/Rhodium/pdf/solventfree.kmno4.oxidation.pdf)

Experience with a permanganate oxidation:

Post 304838 (missing)

(Antimony: "Cheap Easy GHB -No Bromate", Newbee Forum)
Oxid. wth Fe⁺²:/I]
Post 243627 (https://www.thevespiary.org/talk/index.php?topic=11867.msg24362700#msg24362700)
(foxy2: "Ultimate Easy and Cheap THF to GBL", Novel Discourse)
Oxid. wth Peroxyphosphoic acid:/I]
Post 243635 (https://www.thevespiary.org/talk/index.php?topic=11867.msg24363500#msg24363500)
(foxy2: "Re: Easy Oxidation of THF to GBL", Novel Discourse)
Oxid. wth Br₂:
Patent US3074964 (http://l2.espacenet.com/dips/viewer?PN=US3074964&CY=gb&LG=en&DB=EPD)

Catalytic Oxid. with O₂:
Post 364181 (https://www.thevespiary.org/talk/index.php?topic=9181.msg36418100#msg36418100)
(moo: "Catalytic oxidations of THF with 1 atm O2", Methods Discourse)
Oxid. with CoCl₂: Not suggested b/c of nature of oxidant
Post 364181 (https://www.thevespiary.org/talk/index.php?topic=9181.msg36418100#msg36418100)
(moo: "Catalytic oxidations of THF with 1 atm O2", Methods Discourse)
Oxid. with Calium Hypochlorite
Post 3958 (missing)
(Fuchem: "Oxidation of THF to GBL from Tetrahedron Letters", Chemistry Discourse)
Electro-synthesis of GBL from THF:
Post 243610 (https://www.thevespiary.org/talk/index.php?topic=11867.msg24361000#msg24361000)
(foxy2: "Re: Easy Oxidation of THF to GBL", Novel Discourse)
Very similar to the above (from patent SU523093):
Post 381459 (https://www.thevespiary.org/talk/index.php?topic=8946.msg38145900#msg38145900)
(moo: "THF -> GBL patents etc.", Methods Discourse)
Patent US3074964 (http://l2.espacenet.com/dips/viewer?PN=US3074964&CY=gb&LG=en&DB=EPD)

Other References for THF to GBL/GHB:
https://www.thevespiary.org/rhodium/Rhodium/chemistry/thf2gbl.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/thf2gbl.html)

GHB/GBL from Succinic and Maleic acids and anhydrides
Bunch of US patents related:
Post 225945 (https://www.thevespiary.org/talk/index.php?topic=12376.msg22594500#msg22594500)
(encopo: "GHB via GBL/THF via MAN via n-butane", Serious Chemistry)
Post 466341 (https://www.thevespiary.org/talk/index.php?topic=8929.msg46634100#msg46634100)
(Rhodium: "Reduction of Succinic Anhydride to GBL", Methods Discourse)
Post 471608 (https://www.thevespiary.org/talk/index.php?topic=11840.msg47160800#msg47160800)
(Rhodium: "Maleic Anhydride + BDO -Zn/Cu-> 2 GBL", Novel Discourse)

GHB/GBL from Cyclobutanone
Just an idea
Post 67503 (missing)
(Teonanacatl: "Cyclobutanone --> GHB", Novel Discourse)

GBL from GHB
Post 511270 (https://www.thevespiary.org/talk/index.php?topic=6820.msg51127000#msg51127000)
(Rhodium: "Convenient Synthesis of ?-Butyrolactone", Chemistry Discourse)

Physical Properties and Detection of GHB and GBL

Physical Properties and Detection of GHB
https://www.thevespiary.org/rhodium/Rhodium/pdf/ghb-gbl.colortest.pdf (https://www.thevespiary.org/rhodium/Rhodium/pdf/ghb-gbl.colortest.pdf)

https://www.thevespiary.org/rhodium/Rhodium/chemistry/ghb.forensic.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/ghb.forensic.html)

Chromic's Use of the above method for GHB determination (both links):
Post 377846 (missing)
(Chromic: "What the fuck???", Chemistry Discourse)
Post 377847 (missing)
(Chromic: "Dilution was the key", Chemistry Discourse)

Physical Properties and Detection of GBL
https://www.thevespiary.org/rhodium/Rhodium/pdf/ghb-gbl.colortest.pdf (https://www.thevespiary.org/rhodium/Rhodium/pdf/ghb-gbl.colortest.pdf)

https://www.thevespiary.org/rhodium/Rhodium/chemistry/ghb.forensic.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/ghb.forensic.html)

Post 449374 (https://www.thevespiary.org/talk/index.php?topic=6952.msg44937400#msg44937400)
(Rhodium: "Cu Chromite dehydrogenation of 1,4-BD and GBL", Chemistry Discourse)
Post 449918 (https://www.thevespiary.org/talk/index.php?topic=10715.msg44991800#msg44991800)
(LaBTop: "GBL MSDS", Newbee Forum)

Purification of GBL/GHB
Post 214381 (missing)
(foxy2: "PURIFICATION OF GAMMA-BUTYROLACTONE", Chemistry Discourse)

Misc. Stuff I haven't organized yet:
Enzyme stuff
Post 317357 (https://www.thevespiary.org/talk/index.php?topic=6308.msg31735700#msg31735700)
(Chromic: "Some GHB/BDO answers (sorry for the delay...)", Chemistry Discourse)
https://www.thevespiary.org/rhodium/Rhodium/chemistry/ghb.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/ghb.html)
Has information on analogues
Post 446659 (missing)
(OcoteaCymbarum: "Uses for gbl", Chemistry Discourse)
Post 446714 (https://www.thevespiary.org/talk/index.php?topic=8929.msg44671400#msg44671400)
(OcoteaCymbarum: "Industrial production of gbl", Methods Discourse)

Analogues:
https://www.thevespiary.org/rhodium/Rhodium/chemistry/ghb.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/ghb.html)

4-methyl-GHB:
https://www.thevespiary.org/rhodium/Rhodium/chemistry/4-methyl-ghb.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/4-methyl-ghb.html)

MAB and DABD:
https://www.thevespiary.org/rhodium/Rhodium/chemistry/mab.dabd.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/mab.dabd.html)

Articles and Arguments For and Against GHB
Post 412696 (missing)
(runne: "Great article of GHB.", General Discourse)
One of the best write-ups I have personally EVER seen (thanks pharmacist):
Post 403259 (missing)
(pHarmacist: "Thruth About GHB! -DEA, Give Up, you Look Stupid!", General Discourse)
Five part Article:
Post 405869 (missing)
(raffike: "LOTS of info about GHB", General Discourse)
Post 405870 (missing)
(raffike: "In his 1969 review on GHB, anaesthesiologist...", General Discourse)
Post 405871 (missing)
(raffike: "Mamelak has also noted the unique ability of...", General Discourse)
Post 405872 (missing)
(raffike: "GHB has been shown to induce major increases...", General Discourse)
Post 405873 (missing)
(raffike: "In the course of mitochondrial ATP bioenergy...", General Discourse)
Post 317348 (missing)
(Chromic: "GHB: Wernicke-Korsakoff syndrome", General Discourse)
Post 317402 (missing)
(placebo: "Alternative names: Korsakoff psychosis; alcoholic ...", General Discourse)
Post 435795 (missing)
(Rhodium: "Therapeutic GHB does not cause withdrawal", General Discourse)
http://www.projectghb.org/while_sleeping/sld001.htm (http://www.projectghb.org/while_sleeping/sld001.htm)

Addiction to GHB:
http://www.erowid.org/chemicals/ghb/ghb_addiction2.pdf (http://www.erowid.org/chemicals/ghb/ghb_addiction2.pdf)

Pharmacology
https://www.thevespiary.org/rhodium/Rhodium/pharmacology/index.html (https://www.thevespiary.org/rhodium/Rhodium/pharmacology/index.html)
(look under the GHB heading)
Post 275360 (missing)
(Rhodium: "Re: DopamineReplenishment", General Discourse)
Same as above:
https://www.thevespiary.org/rhodium/Rhodium/pharmacology/ghb/ghb.a.new.and.novel.drug.of.abuse.pdf (https://www.thevespiary.org/rhodium/Rhodium/pharmacology/ghb/ghb.a.new.and.novel.drug.of.abuse.pdf)

Dosage:
Post 257448 (missing)
(MaDMAx: "Re: GHB vs GBL ???", Newbee Forum)
THF contamination and its toxicity
Post 490525 (missing)
(7is: "Pharmacology of Tetrahydrofuran", General Discourse)
Post 499157 (missing)
(jsorex: "Copyright © 1996 American Academy of Neurology", General Discourse)

Wanted References of Relevance:
Gouesnard, Jean-Paul; BSCFAS; Bull.Soc.Chim.Fr.; FR; 1; 1989; 88-94 (GHB from GABA)
Tetrahedron Lett. 1968, page 5819; Tetrahedron 1971,vol 27, page 2671
References for Various Oxid. Reagents for use on THF:
Post 67703 (missing)
(SpicyBrown: "Re: New(?) angle on THF > GBL", Chemistry Discourse)

The Vespiary

The Hive => Methods Discourse => Topic started by: Aurelius on June 13, 2003, 09:20:00 AM