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Most phenethylamine, tryptamine, ergoline, etc. drug patents are expired and in the public domain.
Yes actually even almost all of them are.
I don't think it is widely known though, as even designer drugs/research chemicals that so far aren't patented yet, will usually become protected from becoming it ever.
So, like when they are described by forensical chemists, they become unpatent-able, not able to show up described in a patent at first.
I only know this as it happened to a friend of mine, who prepared several novel fluoromethoxyamphetamines, and wanted to patent them as psychotherapeutic invention drugs, and many other claims of a similar nature, psycholytic therapy and such...
His patent was still filed, I have linked it below, but had not applied successfully, due to the mentioned issue.

He was carrying that out purely as a hobby by the way, and while doing them himself, he soon started giving his products aways for free in psycholytic sessions to friends and patients who were recommend by them, but later on for sessions just for the drug use with his friends(actually they considered him as acquintance only, reason given below), yet still for free... but under the condition they use them still at his home.

Then his lab was busted soon after the filed application, and due to being one of the biggest drug labs ever in that certain german state, it was causing literally at least three dozen articles in the largest national newspapers countless else in the tiny local ones.
One was even called "biochemist testing drugs on friends", which indicates he drugged up people against their will... but he doing psycholytic therapy instead, with MDMA mostly but tried other substance too, when the patient was in for it of course.
It even was likely one of the largest designer drugs lab in private hands not doing commercial syntheses.
He once told me, to have made around 40% of his bibles, those being of course Pihkal and Tihkal... I saw proof of it(stil own a few of those proofs, like DOET, what the hell is wrong with anyone using that::)
His suicide has also cause an half dozen article, being something like a celebrity, or maybe thus because it was the only barbiturate related death for like half a century?
Anyway, due to his suicide, I feel free to post his application here, as it contains of course the real name of him.
Here is the patent application of him... https://patents.google.com/patent/DE102011015842A1/en
He would have liked to see it spread, even if the chemistry is all known very much to us...
But involves LiAlH4 reductions fluoro P2NP's though, something Joe only lately has described as being very, very rare, citing just two examples of it... these can be translated easily to unsubstituted LiAlH4 of course, as the fluorine there only causes to change the pharmacological aspects, not the chemical ones... (except the 2-fluoro analogue though, that acts just exactly like plain amphetamine).

I find that sad, as he was one of the last people influenced only by Shulgin instead of Breaking Bad, back then almost everyone pursuing drug chemistry with determination to want to invent new drugs, and most making meth instead only wanted to become cool drug cooks.
Back then, the most major influence before this  series, was probably the dateline episode with strike, I would guess?
Nowadays, due to that damn series(never watched it and never will! It almost ruined the future of the hobby!), everyone who wants to pursue drug chemistry nowadays is itself drawn to make meth due to that series, as it has influenced the public view on the hobby more than anything else ever.
Just claiming to do chemistry as a hobby, even if it just is simple anorganic stuff or other non-drug related stuff, will get you a "are you making meth?" as immediate response from most of the people, not only in the americas but even the whole western world!
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mhmm, i idea 8)
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IMO killing the 'war on drugs' would be a good thing. That abomination is no war on drugs, it is a war waged by the governments of countries upon their own citizens.

***Standing wide eyed a small tear streaks slowly down his face as he begins to slow clap***

Motherfucking-A! Thank you. I wrote a long ass response telling you all the ways I agree with you and how important I think it is for us to stand wittness to the atrocity these tyrants are commiting with the help of their jack booted, traitorous lackey's but it seemed unimportant and redundant. What I thought was important was telling you I fucking think you rock! More people need to be saying this and more people need to really open their ears and listen and comprehend how serious the implications of these are. Man America is makling billions of the prison industrial complex and it is being financed off the misery and suffering of people whose only crime was to choose to medicate themselves without the consent of a government sanctioned dealer. How awful is it that people are flourishing from this knowing that if you remove the title "iegal" from the drugs being done then most if not all of the families that were torn apart by this will be found to have been torn asssunder for NO REASON AT ALL! Jail overcrowding is a thing of the past since 75%+ of them are populated with non-violent drug offenders. Prostiution and the emotional damage occuring both to patrons and "benificiaries" becomes all but extinct. Petty theft becomes almost  a negligible criminal statistic since the price of drugs is inflated almost entirely due to the expenses associated with the black markte... People can have an open dialouge with their health care providers and take prevtative action against healt-risks associated with various drugs. I mean this list continues ad infinitum but no one ever sees it and if they do they still continue to point fingers at everyone but the demons responsible for this plague.... oh well all we can do is stand and bare witness and pray that one day the reckoning will come and those responsible will be called to account by the people who they have transgressed... Again, you rock bro...
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Most phenethylamine, tryptamine, ergoline, etc. drug patents are expired and in the public domain.
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News / Re: A.I. uses "retrosynthesis" to copy patented drugs without infringing patents
« Last post by gd on February 02, 2019, 02:29:14 AM »
i don't see how an alternate synthesis 'gets around' any such copyright infringement but i know nothing about the law.

i do, however, have a grasp on fair play.

surely it is moreso the product that bears the weight of copyright here, regardless of the route taken ?

mind you and having said that, i'm not sure what would happen if software synthed every possible molecular structure, so the method is definitely intellectual property.

Ok I'm most definitely not particularly knowledgeable when it comes to chemistry (or law, for that matter), but...

It seems to me like particular molecular configurations can't possibly be copyrighted since they're totally naturally occuring (even if synthesized in a lab). I mean, it feels like if someone were to copyright gasoline (goodbye 90% of the fuel industry).

I'm not speaking from a place of certainty or anything, but intuitively it just seems like it can't possibly be.

Even syntheses the though... Like, can someone copyright hydrocarbon combustion????

Some food for thought at the very least, that's for sure
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News / Re: A.I. uses "retrosynthesis" to copy patented drugs without infringing patents
« Last post by gd on February 02, 2019, 02:15:35 AM »
Chematica was covered here before, awesome software, I which I had excess to it :D

I would love to play around with Chematica myself, if only I had the chance, but, these huge pieces of proprietary software that charge like $10,000 a license (or something like that) aren't always that much more sophisticated than what open source projects can do (with the right amount of dedication and contribution, at least).

It's like Wolfram / Mathematica / etc... Sure, super useful software if you can afford it (or can get a license by some other means), but totally replicable.

The awesome thing about computer science is that the investments are virtually non-existent. I've only recently gotten into chemistry and it's already costing me a small fortune (glassware, precursors, solvents, and the especially fancy shit like Soxhlet extractors, etc).
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News / Re: A.I. uses "retrosynthesis" to copy patented drugs without infringing patents
« Last post by loft on February 01, 2019, 11:47:14 PM »
Chematica was covered here before, awesome software, I which I had excess to it :D
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News / Re: A.I. uses "retrosynthesis" to copy patented drugs without infringing patents
« Last post by chip on February 01, 2019, 10:24:30 PM »
i don't see how an alternate synthesis 'gets around' any such copyright infringement but i know nothing about the law.

i do, however, have a grasp on fair play.

surely it is moreso the product that bears the weight of copyright here, regardless of the route taken ?

mind you and having said that, i'm not sure what would happen if software synthed every possible molecular structure, so the method is definitely intellectual property.
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News / Re: A.I. uses "retrosynthesis" to copy patented drugs without infringing patents
« Last post by gd on February 01, 2019, 10:57:49 AM »
Quote
The rules are the "basic moves" that are used by graph-search algorithms to navigate enormous trees of synthetic possibilities in intelligent ways.

I just knew I wasn't barking up the wrong tree with my own endeavors (www.thevespiary.org/talk/index.php/topic,16556)...
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News / A.I. uses "retrosynthesis" to copy patented drugs without infringing patents
« Last post by dopamine on February 01, 2019, 05:08:16 AM »
I thought this was pretty interesting, basically this company has developed AI that can reverse engineer drug patents in order to sidestep copyright infringement.  I bet with some tweaking it could also be purposed to sidestep drug laws and create new designer drugs / research chemicals.

Quote
Called Chematica, the software platform does something called “retrosynthesis,” similar to the kind of reverse engineering that takes place when an engineer dissects an existing product to see how it works. In the case of Chematica, this process is based on a deep knowledge of how chemical interactions take place. It has around 70,000 synthetic chemistry “rules” coded into its system, along with thousands of additional auxiliary rules prescribing when particular reactions occur and with which molecules they’re compatible. An algorithm then inspects the massive number of possible reaction sequences in order to find another way to the same finish line.
source: hxxps://www.digitaltrends.com/cool-tech/ai-develop-drug-without-trademark/
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