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Piperonal from 3-4OH Bzaldehyde?

Started by SweetChem, October 30, 2001, 04:13:00 PM

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SweetChem

I don't find any process to synthetize piperonal from 3-4 dihydroxybenzaldehyde. Is it possible to do like the first step of this synth with benzaldehyde insteed benzene?

[url=https://www.thevespiary.org/rhodium/Rhodium/chemistry/safrole.html





... crazy synth for sweet dreams ...

Rhodium

3,4-dihydroxybenzaldehyde is also known as protocatechualdehyde.
Methylenation reactions can be found in

https://www.thevespiary.org/rhodium/Rhodium/chemistry/methylenation.html#methylenation


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SweetChem

Thanks !
But now the problem is that I don't own an autoclave. Is it possible to replace CH2Cl2 by CH2BR2(b.p. 97°)and reflux the whole instead heat under presure?

... crazy synth for sweet dreams ...

Rhodium

Yes, dibromomethane or diiodomethane may be used instead. In the link I posted there are a PTC reaction which does not use an autoclave too.