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ethoxide question.

Started by WHITE_DEVIL, November 19, 2002, 09:59:00 AM

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WHITE_DEVIL

sodium added to ethanol creates sodium ethoxide.
can this be done with any other alcohols?
Methanol?

pHarmacist

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WHITE_DEVIL

Thanks
is it possible to make 'sodium methoxide' and use this turn say, 2,5 di bromo benzaldehyde to 2,5 dimethoxy benzaldehyde (+ 2NaBr)
Also can this be done with other group 1 metals such as Li?

pHarmacist

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Kreist

are used for transethylation of ester groups. Free hydroxy groups will not be methylated. Maybe you could use a quartenary ammonium salt for that?

It is good to have an end to journey toward;
but it is the journey that matters, in the end.

raffike

And there is sodium isopropoxide aswell

A friend with speed is a friend indeed

Rhodium

You could protect the aldehyde function of 2,5-dibromobenzaldehyde as the acetal, then react it with an excess of sodium methoxide in methanol using a catalytic amount of Copper(I)bromide, followed by hydrolysis of the acetal to get 2,5-dimethoxybenzaldehyde.

Both instructions for acetal formation and methoxylation can be found at my page, but exemplified for 3,4,5-trimethoxybenzaldehyde and 5-bromovanillin respectively.