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Post 371398 (missing)

(GC_MS: "simple", General Discourse):
it is mentioned that 2,2,6,6 tetramethylpiperidone was bulky and could have some steric hindrance. does this mean 1. low yield 2. no yield 3. pharmacologically uninteresting fentanyl analog
my main questions are:
if you reacted p-methoxyphenyl-2-bromopropane with tempidone hcl ala seigfried would you get 1-(paramethoxyphenyl-2-propyl) 2,2,6,6 tetrametoxy-4-piperidone in at least 10% yeild?  whould reductive amination with aniline and acylation with acetic anhydride yield an opioid type compound? who cares to guess.  thanks in advance.

#3 is probably the biggest obstacle. I could only find one fentanyl analog reported in the literature with methyl groups in the 2/6 positions of the piperidine ring, and that was only one methyl group. No fentanyls with 2, 3 or 4 methyl groups in the 2/6 positions could be found. The 2-methylfentanyl was reported in

Patent US3923992

thanks.  that kind of information is hard to find.  Looks like its back to methyl acrylate or the double mannich.  My dream compound would be a non-controlled fentanyl analog that is active in the 1-5mg range.  I was looking at loperamide molecules on google and I was amazed at the difference between that and fentanyl, and even loperamide is active with the microgranules.  I think there is a lot of room for finding an active compound that is not specifically listed.  I could mix it with sugar and tell the cops I was making my own rat poison.

if you reacted p-methoxyphenyl-2-bromopropane with tempidone hcl ala seigfried would you get 1-(paramethoxyphenyl-2-propyl) 2,2,6,6 tetrametoxy-4-piperidone in at least 10% yeild?

I'm sure that you would get a considerably higher yield reacting 1-(p-methoxyphenyl)-2-amino-propane (aka PMA) with phorone. The steric hinderance would not be so much of an obstacle as whith the N-alkylation reaction.