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Converting heliotropin to isosafrole or safrole

Started by lastchance, February 26, 2004, 10:31:00 PM

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lastchance

Is there any way to to this?  Any responses would be appreciated.

Kinetic

Yes. You musn't have looked very hard. There are posts here specifically on the use of the Wittig reaction to convert piperonal (heliotropin) to isosafrole. There is also at least one page on Rhodium's site dedicated to the same.

If you're really lazy click here

(https://www.thevespiary.org/rhodium/Rhodium/chemistry/isosafrole.piperonal.html).

cublium

It's possible but probably not worth it as i can see from link above.Convert to nitropropene and reduce that to something or convert to ketone.

GC_MS

I really don't see what this thread is doing in the Serious Chemistry dpt.... If you can get a hold on acetic anhydride, a practical and in the scientific literature well described procedure would be via the Perkin reaction.