News:

Registration doesn't require a real email.
Monero Donation Address: 897ESh4QoJgEytJueBPULziMDfNMToXkGMrvtUCJRo2NQRv2CXACHnmEzeMTkwQhnfcZsAc3ctXp6GsedhMfBv983rn5i84

Main Menu

Leuckart with DMF

Started by josef_k, March 11, 2004, 03:34:00 PM

Previous topic - Next topic

0 Members and 1 Guest are viewing this topic.

josef_k

When you run the leuckart with dimethylformamide you will get the desired amine directly after the reaction with no formyl intermediate. But i'm a bit concerned about the workup. In one example in

https://www.thevespiary.org/rhodium/Rhodium/pdf/leuckart.pdf

they basify with NaOH and then steamdistill. That will ofcourse release much dimethylamine into the air as the DMF is hydrolised, which isn't so nice.

Could you possibly after the reaction extract with DCM (as the amine should be in formate salt) and then basify and extract the amine as usual in an A/B? Is DMF soluable in DCM?

Rhodium

Is DMF soluable in DCM?

Yes, it's miscible with both water and DCM.


terbium

When you run the leuckart with dimethylformamide you will get the desired amine directly
Why do you desire a dimethylamphetamine?


josef_k

No, I was going to run it on deoxybenzoin to get lefetamine.

Rhodium

While lefetamine undoubtedly is a psychoactive compound, it is very weak and has little recreational potential. Consider reductive amination of desoxybenzoin with N-cyclohexylpiperazine instead. The resulting compound is much stronger, see

Post 281338 (missing)

(Rhodium: "Lephetamine/Lefetamine", General Discourse)



josef_k

Yes, i have read that info. However, I want to first make lefetamine for the ease of the reaction, and then perhaps consider making the more potent analogue. And also, I want to get a dean stark trap before trying out the synth of that, as I would probably do it by reductivly aminating with diethanolamine, chlorinating and then reacting with cyclohexylamine (N-cyclohexylpiperazine is pretty expensive).