Hello.
Is going from 4-Hydoxy-Tryptamine into 4-Hydroxy-DiMethylTryptamine possible via any of the routes used to go from tryptamine into dmt? as in this -

https://www.thevespiary.org/rhodium/Rhodium/chemistry/tryptamine2dmt.html

?
Or is this completly impossible because the link between the HO molecule and the Carbon is too weak and will break when subjected to this kind of synthesis route?

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4-Hydoxy-Tryptamine into 4-Hydroxy-Tryptamine

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huu
But yess, iff you have some 4-OH-tryptamine (lucky bastard) you can use the method in the link.

Post 127141

(ejlmp: "Psilocin in 5 steps", Tryptamine Chemistry)

By which method you want to synthesize the 4-hydroxy-indole?

I guess that the one who will choose to follow this reaction would like to purchase the 4-hydroxyindloe from a supplier.

Sorry, 4-hydroxy-tryptamine was meant of course....

Purchasing 4-hydroxy-indole/tryptamine is no good idea (in Lego's opinion) for two reasons:
1) the price
2) it is quite suspicious


Try unsubstituted tryptamine first....

I wonder what would be the effects of 6-ho-DMT if this compound was ever synthesized...

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"It is pretty generally accepted that 6-HO-DMT is inactive. I am not too surprised. There are so few things with open and exposed hydroxyl groups that succeed in making it through the lipid barriers to the brain."

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Alexander Shulgin in

TiHKAL

(http://www.erowid.org/library/books_online/tihkal/tihkal03.shtml#6-HO-DMT)

Beside that 4-OH-tryptamine is quite sensitive, especially even under slightly basic conditions. You would want to protect the hydroxy first with an apropriate group.