reductive amination with mol. sieves and Zn/iPrOH

indole_amine · September 17, 2004, 05:43:00 PM

seems like a nice one-pot method for the reduction of imines with Zn/AcOH...

Synthesis of Bis[di(2-pyridyl)methyl]amine (BDPMA) by a Novel One-Pot Multi-Step Reductive Amination with Molecular Sieves and Zn/iPrOH
(Michael Renz, Catherine Hemmert, Bernard Meunier)
European Journal of Organic Chemistry 1998, 7 (1271-1273)

https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000531876-EuropeanJournalOfOrganicChemistry_Vol_1998_Issue_7_1271-1273_.pdf" target="_blank" title="Download this file">

Keywords
Reductive amination; Zinc; Pentadentate ligand; Polypyridine ligand

Abstract
Bis[di(2-pyridyl)methyl]amine (BDPMA) has been syn-thesized by refluxing di-2-pyridyl ketone and di-(2-pyridyl)methylamine in isopropanol in the presence of molecular sieves and acetic acid and subsequent reduction with zinc dust. The established methods for reductive amination, i.e. NaBH3CN, NaBH(OAc)3 and NaBH4, failed in the synthesis of BDPMA due to a disfavored equilibrium towards the imine formation and therefore long reaction times were required, involving side reactions. The presented method can be used on large-scales and tolerates aromatic heterocycles as functional groups.

_{indole_amine}

Lego · September 18, 2004, 03:06:00 AM

Post 413690

(Lego: "Red. amination with Zn/iPrOH and mol. sieves", Novel Discourse)

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reductive amination with mol. sieves and Zn/iPrOH

indole_amine

Lego