Author Topic: Cyanoborohydride redn. with MeNH2 freebase???  (Read 975 times)

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allalone

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Cyanoborohydride redn. with MeNH2 freebase???
« on: March 27, 2003, 10:50:00 PM »
The search engine and PiHKAL were not as thorough as I had hoped in answering a question I have. Hopefully one of you readers can help.

I (theoretically) added 148 grams MDP2P dropwise to 77 grams of MeNH2 freebase (about 3X molar quantity) in ~700 ml very cold MeOH and stirred it with a handful of silica gel beads for 30 min. Then I decanted the orange solution to a clean flask and added 50 grams NaCNBH3 (about 50% excess over theory). I then let it stir and come to room temperature.

I am now reading about buffering this rxn. with acetic acid, and I understand the purpose and everything, but I was wondering if anyone could give me a more accurate idea of just how much this really affects the reaction, and how necessary it is when using MeNH2 freebase. Anyone?

terbium

  • Guest
Cyanoborohydride reduction as per Org. Syn.
« Reply #1 on: March 28, 2003, 05:59:00 PM »
The Org. Syn. procedure does not call for any acetic acid.

http://www.orgsyn.org/orgsyn/prep.asp?prep=cv6p0499