Author Topic: Sodium Borohydride vs Sodium Cyanoborohydride  (Read 641 times)

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aleph

  • Guest
Sodium Borohydride vs Sodium Cyanoborohydride
« on: October 28, 2003, 12:27:00 AM »
Anyone have a clue whether sodium borohydride rather than sodium cyanoborohydride will work in Strike's (Total Synthesis II) method #1 (page 98)?

A post I have seen indicates it may be a possibility, but indicates the use of methylamine gas.  I was hoping for the easy reaction in Strike's book without cyanoborohydride.


cublium

  • Guest
Borohydride will work with methylamine just...
« Reply #1 on: October 28, 2003, 06:50:00 AM »
Borohydride will work with methylamine just fine althought cyanoborohydride will give slightly higher yields(it doesn't reduce ketone to alcohol,which borohydride does,but only imine to amine).

aleph

  • Guest
Thanks
« Reply #2 on: October 29, 2003, 11:32:00 PM »
Thanks for the info.