Author Topic: THC solubility?  (Read 922 times)

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adroit_synth

  • Guest
THC solubility?
« on: January 22, 2004, 07:04:00 AM »
SWIM has an ounce of an old IPA extract and would like to get rid of some waxes, if not all (it is a big black sticky blob at this point). If anyone could provide detailed solubility data for THC or point him to some solvents to more selectively extract the active principal from this mess of organic junk, he would be thrilled.


adroit_synth

  • Guest
butane
« Reply #1 on: January 22, 2004, 03:43:00 PM »
SWIM is aware of the butane method and may have to resort to it but he cannot find large amounts of pure, inexpensive butane at this point. He would very mcuh like a more selective solvent then IPA or a temperature of a particular solvent that does not hold many waxes (even IPA perhaps?).


adroit_synth

  • Guest
Newbee
« Reply #2 on: January 23, 2004, 06:02:00 PM »
Alright guys. This was apparently a Newbee question because the mods moved it here. So what is the problem? No one can simply tell SWIM what he should do? He would usually mess around and try to figure it out himself but he does not have enough to risk such a waste b/c dissolving in a bunch of different solvents and temperatures will cause a large loss in active product. No one has had hash that sucked and tried to improve it??? I find that hard to believe considering the types of minds present here.


Nicodem

  • Guest
Maybe nowbody gives an answer simply because...
« Reply #3 on: January 23, 2004, 06:35:00 PM »
Maybe nowbody gives an answer simply because nobody ever goes trough the trouble of geting rid of the waxes and clorophyls when making some hash oil. I always smoke it like "a big black sticky blob" and never complain (usually i sprinkle drops of acetone dilluted hash oil on tabaco, mix it well and let it dry or you can smoke it on Alu-foil). It is still better than loose half of the THC and contaminate it  with some stinking hydrocarbons.


Rhodium

  • Guest
Work
« Reply #4 on: January 23, 2004, 10:05:00 PM »
You could easily column chromatograph it through some alumina or silica gel, but I assume that is too much work for most stoners  ;)


embezzler

  • Guest
chromatography
« Reply #5 on: January 24, 2004, 12:13:00 AM »
would be willing to try that just for experiment sake. do you have a web referance or do i just bundle hash oil into a column of the gels and collect the seperate products at the end. and can those gels be synthesised or just bought?

Psi_Locybe

  • Guest
I second...
« Reply #6 on: January 24, 2004, 12:17:00 AM »
For starters, I second Rhodium's chromatography suggestion.  With vehemence.  If you're feeling ultra-ghetto, and don't feel like going to the florist's for silica - use a fucking tampon, for crying out loud!

 Alternately, a person could dump their crude hash into a test tube, fire it up to about 180c into the open air for a while, let it cool down, and then distill at about 200c into ethanol.  Makes a stiff drink, I can tell ya that much.  ;)

 Still alternately, one could take one's crude acetone extract, crash out the oils with H2O, and then anything water-soluable will be in the water, whereas the layer of oil will be... erm... non-water-soluable.

...if one's feeling really, REALLY creative, one can crash with dH2O a bit at a time... have lots of little vials... "These are the oils soluable in 99.999% acetone, but not 99%," "these are the oils soluable in 99% acetone, but not 98%," etc.

Some combination of these techniques should theoretically yield 99.999% pure d-9-THC.  Any one alone should yield "at least as close as you were asking..."

...personally, I like the notion of chromatographing the distillate of a dH2O washed and/or fractionated extract.... but whatever works in your world...

..."don't take it all at once, kid"... lol.


adroit_synth

  • Guest
purification
« Reply #7 on: January 24, 2004, 11:32:00 PM »
SWIM has a vacuum fractional distillation setup as well as a few eBooks on chromatography that he has not read yet. He also has a pound of silica gel (is this enough to contruct a reasonable column?) and will research and post his results.

adroit_synth is not the stereotypical pothead. It's all a head game and requires the proper attitude to win. L-Glutamine supplementation takes care of the pesky problem of not being able to make rational connections and think logically while stoned as it is displaced when you smoke. Marijuana is pretty hard on the adrenals as well and an adrenal care regimen should be implemented. This includes phosphatidylserine (the chemical connection between your adrenals and brain) and a timed release pantothenic acid (food for the adrenals) pill. This will ensure that the adrenal reserves do not become depleted and lead to irratibilty, poor sugar metabolism and much, much more. Most people in today's stressful society are stifled by adrenal exhaustion, significantly impairing there productivity and sense of wellness. I think if one feels inclined to ingest a particular substance he should be aware of how that substance affects his biochemistry and take care to implement procedures to correct any imbalances produced as a result.


lugh

  • Guest
Solvent Selectivity
« Reply #8 on: January 25, 2004, 01:51:00 AM »

If anyone could provide detailed solubility data for THC or point him to some solvents to more selectively extract the active principal from this mess of organic junk, he would be thrilled.





Maybe nowbody gives an answer simply because nobody ever goes trough the trouble of geting rid of the waxes and clorophyls when making some hash oil.




Obviously it's difficult for a newbee to understand this, but repetitive questions are rather irritating, and not likely to be answered at all  ;)  It's well known that hydrocarbon solvents are more selective than alcohols or ketones, as you would have found out if you had used the search engine and found

Post 209842 (missing)

(lugh: "Re: CO2 HASH OIL", Methods Discourse) or many other posts on THC solvents  :P






Psi_Locybe

  • Guest
Heyyyy... buddy...
« Reply #9 on: January 25, 2004, 06:12:00 AM »
I think if one feels inclined to ingest a particular substance he should be aware of how that substance affects his biochemistry and take care to implement procedures to correct any imbalances produced as a result.

I think I'm in love.  :)  Mind if I 'sleaze on up?'  The intercourse is all intellectual, after all...

...the pesky problem of not being able to make rational connections and think logically while stoned...

Could you elaborate slightly?  'cause if "what I think you *could* be talking about" and "what you are talking about" are the same thing, I personally would phrase it differently - but how the hell does one describe "what happens when you're stoned," anyways, y'kno?

 If you speak of "what your description sounds like to me," I have absolutely no such problem while blazed - but would love to overjack reasonably on the day-to-day nootropic side.  If you speak of "what I've experienced that is the closest to your description..."

...that could indeed be interesting.  Tell me more...

Marijuana is pretty hard on the adrenals as well and an adrenal care regimen should be implemented.

...I've noticed this, from time to time - though "hard" compared to, say, ephedrine (hey - I don't do meth.  I don't like meth.  What I don't like about meth, ephedrine doesn't do.  Your milage may vary) is a bit different than, say, "be aware."

...bioassay-wise, I've noticed that herb seems to be a unique broad-spectrum tryptamine/phenethylamine release agonist, IMHO... adrenaline noted, occasional illustration of less-than-full dopamine, where existant...

...and, well...

Did y'ever just drop 300mg of nice, clean tryptophan onto your oral membranes, accept the schwagged-out melatonin production at days 3 and 4, recover (with mad broad-spectrum tryptamine long-term storage)...

...and then spend the weekend after smokin' twumps 'till ya grill?  Ganj deliberately directed towards being a visionary hallucinogen is... interesting.  Especially since it's... still... ganj...

...anyways...

This includes phosphatidylserine (the chemical connection between your adrenals and brain)...

Oooh... got any further detail on the finer points of 'connection,' perchance?  ;) ;)

...a timed release pantothenic acid (food for the adrenals) pill.

Eh... at the level of... which... PEA beta-hydroxylase, or...?

This will ensure that the adrenal reserves do not become depleted and lead to irratibilty...

...I've always personally associated that specific with the pre-adrenal, namely dopamine, ever since my lobelidine-group days...

...lack of energy and a fucked up sleep/wake cycle sucks, though...

Most people in today's stressful society are stifled by adrenal exhaustion, significantly impairing there productivity and sense of wellness.

Heh.  That's why I roll with a q.p. of phenylalanine acetate at a time.  :)

...I think I like you.  You're right up my wavelength, it appears...

...keep in touch, k?


adroit_synth

  • Guest
hmm
« Reply #10 on: January 25, 2004, 07:03:00 AM »

I think I'm in love.  :)  Mind if I 'sleaze on up?'  The intercourse is all intellectual, after all...




Why not?

I will post more on the chemical connection and imbalances I speak of shortly. I am away from my house now and will post when I return.

Lugh: Thanks for the link and the smile, the dumb fucker GIF cracks me up everytime. My apologies for being such a poor searcher, I must have overlooked it for I have no CO2. Hopefully when I post my method and results Newbees will benefit (but then they wouldn't see your GIF). :P




adroit_synth

  • Guest
elaboration
« Reply #11 on: January 26, 2004, 05:59:00 AM »

...the pesky problem of not being able to make rational connections and think logically while stoned...
Could you elaborate slightly?




Of course. It affects everyone differently, some (but not all) variables include:
 - Present adrenal condition(as this affects cognitve function); hypo/hyper active adrenals, Parkinsons's, adrenal exhaustion, adrenal hysteria (induced by a stressful lifestyle and/or chronic use of marijuana. If not kept in check, will lead to adrenal exaustion), etc.
 - Baseline intellectual ability. You see, if most of what  you think about hardly stresses your ability to compute then how would you know if your capacity was diminished slightly as it would not require much more effert anyhow. For those whith less than superb intelligence, the wrath is felt much stronger.
 - Amino acid consumption and balance. Eating enough protein?
 - Tolerance.
 - Health, generally. :P

Now, for the L-Glutamine, one with a greater deficiency would see a greater benefit from supplementaion. If you eat healthfully and consume adequate amounts of whole proteins, then you probably do not have such a noted loss of intellect. For cognitave function under any circumstances, vinpocetine (cerebro vasodilater, derived from periwinle) has been noted to markedly increase information processing speed and attention span.


This includes phosphatidylserine (the chemical connection between your adrenals and brain)...

Oooh... got any further detail on the finer points of 'connection,' perchance? ;) ;)



hmm.. lets see what we can do for ya...

...ahh yes! I owe many thanks to this book about adrenal exhaustion and how to undo it.

Hanley, Jesse, M.D., and Nancy Deville. Tired of Being Tired. The Berkley Book Publishing Group, 2002.

"Phosphatidylserine, which is a brain nutrient, helps rebalance pituitary/adrenal communication and nourishes and supports adrenals while you rest. For those who suffer from insomnia because their adrenals are turning on innapropriately at night, PS can help. You know this happening when you routinely awake in the middle of the night once, twice, or more times a night. You may experience your heart beating rapidly and/or you have to get up and go to the bathroom all night long. PS influences your brain's messages to your adrenals so that they stop the innapropriate release of adrenaline, cortisol and DHEA."

Well activation of the hypothalamic-pituitary-adrenal axis is not the only thing PS modulates.

from

http://www.thorne.com/pdf/journal/1-2/phosphatidylserine.pdf



Abstract Working in the cell membrane milieu, phosphatidylserine (PS) is a nutrient that supports membrane proteins crucial for homeostasis, maintenance, and specialized cell functions. PS is found most concentrated in the brain, where its relative abundance reflects its involvement in specialized nerve cell functions such as chemical transmitter production and release, receptor action, and synaptic activity. The fundamental contributions of PS to the structure and function of individual nerve cells are expressed in the performance of the brain as a whole. More than 35 human studies that span almost 3 decades, together with numerous animal studies, indicate PS supports EEG integration, the HPAA (hypothalamic-pituitary-adrenal axis), and circadian rhythms of hormone release. Some sixteen clinical trials indicate that PS benefits measurable cognitive functions which tend to decline with age; these include memory, learning, vocabulary skills and concentration, as well as mood, alertness, and sociability. PS is a phospholipid, ubiquitous in membranes and obligatory for all the cells of the body. Present in common foods in small amounts, PS may be a semi-essential nutrient. Although it can be synthesized in vivo from precursors, its multistep biosynthesis is energetically costly. Until recently, supplemental PS was available only from bovine brain. Now PS is available as a soy lecithin-based concentrate. With its proven benefits against agerelated mental decline, phosphatidylserine might represent a truly safe and effective means for improving the quality of life of the elderly. (Alt Med Rev 1996;1(2):70-84) The progressive loss of mental agility with age has become a major focus of basic and clinical research efforts. Beginning around midlife, the brain’s higher functions of memory, learning, semantic manipulation, and concentration (collectively referred to as cognition) measurably begin to fade. The ancient writer Virgil put it best in 70 B.C.: “Age takes away all things, even the mind.” An impressive body of human studies with PS, published over a span of almost 3 decades,1-35 now makes possible an optimistic approach to conserving those brain functions that decline with age.


...a timed release pantothenic acid (food for the adrenals) pill.

Eh... at the level of... which... PEA beta-hydroxylase, or...?



I will have to get back to you on the specifics of what enzymes systems are affected by B-5.


This will ensure that the adrenal reserves do not become depleted and lead to irratibilty...

...I've always personally associated that specific with the pre-adrenal, namely dopamine, ever since my lobelidine-group days...

...lack of energy and a fucked up sleep/wake cycle sucks, though...



Dopamine supplementation would downregulate dopamine receptors, IMHO. This would result in a worse feeling when you ceased supplementation than when you started it. B-5 as I have stated, is a nutrient for the adrenals and nourishes them, facilitating their normal functions. On the contrary, adminsitration of DHEA or any catecholamine will in a sense, replace the adrenal functions, facilitating atrophy and Parkinsonism. Catacholamine abuse will rapidly deteriorate the adrenals. First hysteria, then depletion, then exhaustion, then your fucked and you do not want to go on anymore, problems seem worse and worse...

Interestingly enough, my adrenals were completely fucked from wrestling endurance practices and fasting to lose weight. It forced me to think more about things b/c I almost died and recovered very slowly, which forced me to launch an investigation of my own physiology. This investigation after many fruitless leads, came to adrenal exhaustion. So I followed some rejuvenation guidelines and everything just kept getting better. :)  

Well, that's it for now. I can most likely dig up much more information upon request. ;)