Author Topic: tempidone fentanyl  (Read 565 times)

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albert_grieves

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tempidone fentanyl
« on: January 26, 2004, 08:01:00 PM »
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Post 371398 (missing)

(GC_MS: "simple", General Discourse)
:
it is mentioned that 2,2,6,6 tetramethylpiperidone was bulky and could have some steric hindrance. does this mean 1. low yield 2. no yield 3. pharmacologically uninteresting fentanyl analog
my main questions are:
if you reacted p-methoxyphenyl-2-bromopropane with tempidone hcl ala seigfried would you get 1-(paramethoxyphenyl-2-propyl) 2,2,6,6 tetrametoxy-4-piperidone in at least 10% yeild?  whould reductive amination with aniline and acylation with acetic anhydride yield an opioid type compound? who cares to guess.  thanks in advance.

Rhodium

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2-methylfentanyl
« Reply #1 on: January 27, 2004, 07:48:00 AM »
#3 is probably the biggest obstacle. I could only find one fentanyl analog reported in the literature with methyl groups in the 2/6 positions of the piperidine ring, and that was only one methyl group. No fentanyls with 2, 3 or 4 methyl groups in the 2/6 positions could be found. The 2-methylfentanyl was reported in

Patent US3923992




albert_grieves

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thanks. that kind of information is hard to...
« Reply #2 on: January 27, 2004, 10:25:00 AM »
thanks.  that kind of information is hard to find.  Looks like its back to methyl acrylate or the double mannich.  My dream compound would be a non-controlled fentanyl analog that is active in the 1-5mg range.  I was looking at loperamide molecules on google and I was amazed at the difference between that and fentanyl, and even loperamide is active with the microgranules.  I think there is a lot of room for finding an active compound that is not specifically listed.  I could mix it with sugar and tell the cops I was making my own rat poison.

Nicodem

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PMA+phorone=>your 2,2,6,6-tetraMe-4-piperidone
« Reply #3 on: January 27, 2004, 10:55:00 AM »
if you reacted p-methoxyphenyl-2-bromopropane with tempidone hcl ala seigfried would you get 1-(paramethoxyphenyl-2-propyl) 2,2,6,6 tetrametoxy-4-piperidone in at least 10% yeild?

I'm sure that you would get a considerably higher yield reacting 1-(p-methoxyphenyl)-2-amino-propane (aka PMA) with phorone. The steric hinderance would not be so much of an obstacle as whith the N-alkylation reaction.